CODAGE MOLÉCULAIRE ET NEURONAL DES COMPORTEMENTS
Département : Neurosciences
Thème de recherche
Selection and execution of appropriate behavioral responses rely on the ability to properly use sensory information to predict future rewards or punishments. The dorsal striatum, the nucleus accumbens and the extended amygdala are major structures critically involved in this learning process. The general objective of our research aims to characterize the molecular mechanisms resulting from the integration of dopamine and glutamate signals and to understand the functional impact of such events on dopamine-controlled learning and pathology.
Équipe
Chef d'équipe
Chercheurs
Techniciens et ingénieurs
Chercheurs CDD et doctorants
Techniciens et ingénieurs CDD
Publications majeures
- Biever A, Puighermanal E, Nishi A, David A, Panciatici C, Longueville S, Xirodimas X, Gangarossa G, Meyuhas O, Hervé D, Girault JA, Valjent E. PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spint neurons. J Neurosci. 2015 35(10):4113-30.
- Puighermanal E, Biever A, Espallergues J, Gangarossa G, De Bundel D, Valjent E. Drd2-Cre:RiboTag mouse line unravels the possible diversity of dopamine D2 receptor-expressing cells of the dorsal mouse hippocampus. Hippocampus 2015 (ahead of print).
- Pascoli V, Terrier J, Espallergues J, Valjent E, O'Connor EC, Lüscher C. Contrasting forms of cocaine-evoked plasticity control components of relapse. Nature 2014 509(7501):459-64.
- Gangarossa G, Espallergues J, Mailly P, De Bundel D, de Kerchove d’Exaerde A, Hervé D, Girault JA, Valjent E, Krieger P. Spatial distribution of D1R- and D2R-expressing medium-sized spiny neurons differs along the rostro-caudal axis of the mouse dorsal striatum. Front Neural Circuits 2013 7:124.
- Gangarossa G, Longueville S, De Bundel D, Perroy J, Hervé D, Girault JA, Valjent E. Characterization of dopamine D1 and D2 receptor-expressing neurons in the mouse hippocampus. Hippocampus 2012 22(12):2199-207.