- ENGINEER POSITION – BIOCHEMICAL ANALYSIS OF T-TYPE CALCIUM CHANNEL PROTEOME IN PAIN NEURONAL NETWORKS
BOURINET Lab (Calcium channel dynamics & nociception)
Institut de Génomique Fonctionnelle, Montpellier, FRANCE
An engineer position (IE level) in biochemistry is immediately available in the group of E Bourinet, funded by the Agence Nationale pour la Recherche. The appointment will be made for 20 months, starting as soon as possible. The engineer will use biochemical approaches to immunoprecipitate the GFP tagged Cav3.2 calcium channel from spinal cord and brain of Cav3.2-GFP KI mouse generated in the team. The approach will use a panel of anti GFP nanobodies that will need to be produced. The engineer will team up with a postdoc and researchers in the lab to identify Cav3.2 partners in neuronal networks implicated in chronic pain in relation with the main project of the team aimed at understanding Cav3.2 impact to pain pathophysiology.
Francois et al (2015) Cell Rep.10(3) 370-382; Garcia-Caballero et al. (2014) Neuron 83(5):1144-1158 ; Marger et al. (2011) Proc Natl Acad Sci U S A 108(27):11268-11273. Bourinet et al. (2005) Embo J 24(2):315-324. ; Reynders et al. (2015) Cell Rep 10(6):1007-1019. ; Francois et al. (2013) Pain 154(2):283-293.
We are seeking highly motivated and skilled candidates (level ingénieur d’étude) with a solid expertise in biochemistry (immunoprecipitation, co immunoprecipitation, proteomic, protein production in bacteria, molecular biology) and in rodent manipulation (injections, perfusion, dissections) to succeed in identifying Cav3.2 partners within the channel signaling complexes in neurons involved in pain perception. The applicant will work in a team environment as well as with the IGF proteomic platform to advance scientific programs funded by the ANR and the Fondation pour la Recherche Médicale.
Funding for 20 months (10 months renewable).
Monthly salary of 2004 to 2260€ depending on experience (1614 to 1840 € net)
- IGF SEEKING POST-DOC POSITION
Foldamer and Stapled peptide as inhibitors of PXR: an alternative therapeutic strategy for sensitizing cancer cell and stem cells to chemotherapy
Colorectal cancer (CRC) is the third most common newly diagnosed cancer and the third most common cause of cancer death. Current standard-of-care treatments include surgery, radiotherapy and chemotherapy, sometimes in association with targeted therapies. However, treatment efficiency is severely hampered by the frequent occurrence of drug resistance and post-treatment tumor recurrence. In recent years, highly tumorigenic subpopulations of cancer cells, the so-called cancer stem cell (CSCs), have been implicated in tumor initiation, metastasis and drug resistance leading to post-treatment tumor recurrence. In this context, our objective is to identify specific PXR inhibitors to sensitize cancer stem cells to chemotherapy.
More informations on this link : Post doc position
- IGF SEEKING ENGINEER POSITION - NEUROIMAGING OF MITOCHONDRIAL FUNCTION
An engineer position (IE level) in neuroimaging is immediately available in the group of Freddy Jeanneteau, funded by the Fondation pour la Recherche Médicale. The appointment will be made for 24 months, starting at latest the 1st of september.
More informations on this link : ENGINEER POSITION
- IGF SEEKING NEW GROUP LEADERS
The Institute of Functional Genomics (IGF) (www.igf.cnrs.fr), located in Montpellier, France, is seeking two new group leaders.
More informations on this link : IGF SEEKING NEW GROUP LEADERS
IGF SEEKING POST-DOC POSITION IN CANCER TO WORK ON THE MECHANISM OF HEART RATE REGULATION
More information on this link : POST DOC POSITION