Team Philippe MARIN
Neuroproteomics and signalling of brain disorders
Philippe
Marin
DRCE, CNRS
The team is developing a multidisciplinary strategy combining genomics and proteomics approaches with pharmacological, biochemical, cell biology, electrophysiological and behavioral studies to decipher the neuronal mechanisms involved in various neurological and psychiatric disorders (mood disorders, psychoses, autism, Alzheimer’s disease, multiple sclerosis) and identify biomarkers of these pathologies.
Our research aims at characterizing the pathophysiological mechanisms of neurological (Alzheimer’s disease, multiple sclerosis, gliomas) and psychiatric (depression, schizophrenia, autism spectrum disorders) disorders, in order to identify targets for innovative therapies and biomarkers. It cover molecular mechanisms, with a focus on signaling networks associated with various G protein-coupled receptors that are potential targets for the pathologies studied (serotonin, glutamate and chemokine receptors), which we characterize using interactomic or phosphoproteomic screens, cellular mechanisms (intracellular trafficking, secretion and paracrine diffusion of pathological proteins), synaptic mechanisms (transmission and plasticity) and changes in brain connectivity and network activity, in particular alteration of the excitation/inhibition balance. Particular attention is paid to neurodevelopmental mechanisms and environmental factors (microbiota, diet, etc.). The team is also deeply involved in environmental issues and the impact of climate change on mental health.
Within this general framework, the team is developing the following lines of research under the direction of project leaders:
• Interactomics and neuropathologies
• Microbiota, serotonin and Alzheimer’s disease
• Protein trafficking and neurodegenerative diseases
• Signaling networks associated with antipsychotic targets
• Serotonin receptors, mood disorders and psychoses
• Serotonin receptors and neurodevelopmental pathophysiology
• Multiple sclerosis: environmental factors and biomarkers
Colocalization of ACKR3 and Connexin 43 (receptor’s partner identified by interactomics) in mouse brain astrocytes. ACKR3 (cyan), Cx43 (pink), GFAP (white). Adapted from Fumagalli et al. Nat. Commun. 2020.
Team leader
Philippe
Marin
IGF Sud 215
04 34 35 92 42Know more >
Philippe
Marin
DRCE, CNRS
Team: Philippe Marin
EDUCATION
-
1999Accreditation to Supervise Research (HDR), Life Sciences specialty - Pierre et Marie Curie University - Paris - France
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1992PhD in Molecular and Cellular Pharmacology - Pierre et Marie Curie University - Paris - France
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1988Agrégation of Biochemistry - École Normale Supérieure de Cachan - Paris - France
POSITIONS HELD
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2005-Head of the "Neuroproteomics and Signaling in Brain Pathologies" team at the Institute of Functional Genomics (IGF) - Montpellier - France
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2005-Research Director at CNRS
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1993-2005Research fellow at CNRS
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1989-1993PhD student (holder of a fellowship from the Direction des Recherches, Études et Techniques (DRET)
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1985-1989Student at École Normale Supérieure de Cachan - Paris - France
HONORS / RESPONSABILITIES
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2021-Director of the Institute of Functional Genomics of Montpellier (21 teams, ~360 people)
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2021-Member representing the CNRS of the "Comité de la Recherche en matière Biomédicale et de Santé Publique (CRBSP)" of Montpellier University Hospital
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2018Director of the IGF Neuroscience Department (12 teams, ~200 people)
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2017-Co-manager of the Neuroscience Axis of the Biology and Health Pole of the University of Montpellier
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2016-2020Member of the FRM Scientific Council
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2014-2017President of the French Proteomics Society (SFEAP)
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2011-2020Director of the Proteome Pole of Montpellier-Languedoc Roussillon (PPM, regional proteomics platform with IBiSA accreditation)
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2011-2020Scientific Manager of the IGF Functional Proteomics Platform, the main site of the PPM
SKILLS / EXPERTISE
- Following a training in biochemistry, neurobiology and pharmacology, I specialized in proteomics, which my team applies to discover new signaling mechanisms triggered by serotonin and other neurotransmitter receptors, as well as novel regulatory mechanisms of these systems potentially involved in various neurological and psychiatric diseases. We also use proteomics to characterize new biomarkers of these pathologies.
Researchers
Carine
Becamel
IGF Sud 224 04 34 35 92 15Know more >
Carine
Becamel
MCF, UM
Team: Philippe Marin
EDUCATION
-
2017Accreditation to Supervise Research (HDR) - Univ. Montpellier - France
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2002PhD in Biochemistry/Neurosciences - Univ. Montpellier - France
POSITIONS HELD
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2005-Associate professor in Neuroscience - Faculty of Medicine of Montpellier-Nîmes - France
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2002-2005Postdoctoral fellow - Dr. R. Malinow's team - CSHL - NY - USA
HONORS / RESPONSABILITIES
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2023Elected member (substitute) of the Human Resources Committee - Biology & Health Scientific Department - Univ. Montpellier
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2022-Appointed Faculty Referent Against Gender-Based and Sexual Violence - Medical School of Montpellier-Nîmes - Univ. Montpellier
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2021-Appointed Handiversity Teacher Referent - Medical School of Montpellier-Nîmes - Univ. Montpellier
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2014-Elected member at the Board of the Medical School of Montpellier-Nîmes - Univ. Montpellier
SKILLS / EXPERTISE
- I am a neurobiologist. By combining pharmacological, biochemical and proteomic approaches to electrophysiological and behavioural analyses, I developed ambitious projects aimed at characterizing the modulatory role of serotonin receptors on synaptic plasticity and cognitive functions dependent on prefrontal cortex as well as their involvement in psychiatric disorders such as schizophrenia and depression.
Joel
Bockaert
IGF Sud 215 04 34 35 92 42Know more >
Joel
Bockaert
PU, UM
Team: Philippe Marin
EDUCATION
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1973PhD in Natural Sciences - Paris - France
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1968Agrégation de Sciences Naturelles - Paris - France
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1964Entrance examination to École Normale Supérieure (Ulm) - Paris - France
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1961École Normale d'Instituteurs entrance exam - Mérignac - France
POSITIONS HELD
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2014-Professor Emeritus University of Montpellier - France
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2001-2014University Professor (PRCE) - Univ. Montpellier I - France
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1988-2001Director of Research (1st Class) CNRS
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1997-2001Director of Research (Exceptional Class), CNRS
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1985-1989Associate Professor, Université des Sciences et Techniques du Languedoc - Montpellier - France
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1982Research Director (2nd Class), CNRS
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1973-1982Assistant Director of the Cellular Physiology Chair, Collège de France - Paris - France
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1973-1974Postdoctorate (Dir. Lutz Birnbaumer) - Northwestern University - Chicago - USA
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1973Assistant Professor - University of Paris VI - France
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1968Assistant at the Faculty of Science - Paris - France
HONORS / RESPONSABILITIES
- Awards/Distinctions
- Member of the French Academy of Sciences
- Member of the Montpellier Academy of Science and Literature
- Member of EMBO
- Chevalier de la Légion d'Honneur
- Palmes académiques
- Scientific responsibilities
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2013-2019Director of the Montpellier Biology and Health Cluster
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2010-President ANR Neurosciences White Program
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2009President ANR Neurological and Psychiatric Diseases
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2000-2006Director of Génopole Montpellier Languedoc Roussillon
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2000-2003Chairman of the Scientific Council of the MENRT IFR program
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1999Elected Chairman of the Scientific Committee of the FENS 2000 Congress in Brighton
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1995-2000Elected member of the Scientific Committee of La Fondation pour la Recherche Médicale
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1995-2000President of Section 25 of the Comité National de la Recherche Scientifique (French National Scientific Research Committee)
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1992-1995President of the Société des Neurosciences
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1992-1995Member of the Scientific Council of the Ligue Nationale contre le Cancer (National League against Cancer)
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1991-1995Chairman of INSERM Specialized Scientific Commission no. 5 "Signaling and intracellular transport"
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1981-1985Nominated member of ATP (Action Thématique Programmée) "Neuromediator Receptors"
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1983Elected member and Secretary of the CNRS National Committee (Commission n°25 - Cellular Interactions)
SKILLS / EXPERTISE
- Neuroscience
- Neuropharmacology
- Genomics
Olivier
Caillard
IGF Sud 224 04 34 35 92 15Know more >
Olivier
Caillard
CRCN, CNRS
Team: Philippe Marin
EDUCATION
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1999PhD in Molecular Pharmacology & Cellular Physiology - Paris VI University
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1994DEA in Molecular Pharmacology & Cellular Physiology - Paris VI University
POSITIONS HELD
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2025-CNRS Research Scientist - Institute of Functional Genomics (IGF) - Montpellier
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2012-2018CNRS Research Scientist - INSERM UMR 1072 - Marseille
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2004-2012CNRS Research Scientist - INSERM UMR 641 – Marseille
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2000-2004CNRS Research Scientist - INSERM U29 – Marseille
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1999-2000Post-Doctorat - Max Planck Institute für Biophysikalische Chemie – Göttingen
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1995-1999PhD thesis – INSERM U29 - Paris
HONORS / RESPONSABILITIES
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2009-Scientific Expert Ministry of National Education and Research
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2004-2012Board Member of Young researcher Bureau at French Neuroscience Society
SKILLS / EXPERTISE
- I am an electrophysiologist specialized in the electrical activity of cortical and hippocampal neurones
- Synaptic transmission, short and long-term plasticity
- Intrinsic Excitability and its plasticity
- Modelisation of synaptic activity and Input/output relationship
Séverine
Chaumont-Dubel
IGF Sud 029 04 34 35 92 17Know more >
Séverine
Chaumont-Dubel
MCF, UM
Team: Philippe Marin
EDUCATION
-
2016HDR - University of Montpellier - France
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2004PhD in Molecular and Cellular Biology - University of Montpellier - France
POSITIONS HELD
-
2009-Associate Professor - Institute of Functional Genomics - University of Montpellier - France
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2007-2009Postdoctoral training (Dir. Dr M. Garret) - Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA) - Bordeaux - France
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2006-2007Postdoctoral training (Dir. Dr B. Khakh) - David Geffen School of Medicine, Department of Physiology and Neurobiology - University of California Los Angeles - USA
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2004-2006Postdoctoral training (Dir. Dr B. Khakh) - Laboratory of Molecular Biology - Cambridge - England
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2001-2004Thesis (Dir. F. Rassendren) - Institute of Functional Genomics - Montpellier - France
HONORS / RESPONSABILITIES
- Deputy Director of UAR BioCampus
- Scientific co-manager of the Functional Proteomics Platform (FPP)
- Co-responsible for relations with LAS institutional partners for the University of Montpellier
SKILLS / EXPERTISE
- Specialist in molecular biology, biochemistry and neuroproteomics. My project focuses on the neurodevelopmental roles of the serotonin 5-HT6 receptor, an emerging target for the treatment of cognitive deficits associated with neurodevelopmental pathologies.
Sylvie
Claeysen
IGF Sud 224 04 34 35 92 15Know more >
Sylvie
Claeysen
CRHC, Inserm
Team: Philippe Marin
EDUCATION
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2009Habilitation to Supervise Research (HDR) - University of Montpellier - France
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1999PhD - Biochemistry & Molecular Biology - University of Montpellier - France
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1995Master's degree - Health Biology - University of Montpellier - France
POSITIONS HELD
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2023-Senior Researcher at INSERM, Institute of Functional Genomics (IGF) - Montpellier - France
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2002-2022Junior Researcher at INSERM, Institute of Functional Genomics (IGF) - Montpellier - France
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2000-2002Postdoctoral fellow, Institute of Interdisciplinary Research in Human and Molecular Biology (IRIBHM) - Brussels - Belgium
HONORS / RESPONSABILITIES
- Awards
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2024-2026Research and Doctoral Supervision grant (PEDR)
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2020-2023Research and Doctoral Supervision grant (PEDR)
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2016Member of the Inserm cross-cutting Program Microbiota
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2013Junior Faculty Award - AD/PD™ 2013 - The Alzheimer's & Parkinson's Conference
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2012Chercheuse d'avenir 2011 of the Languedoc Roussillon Region
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2011Soroptimist International (French Union) Medal
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2010France Alzheimer Research prize 2010
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1997Roche Bioscience Prize - Advances in Serotonin Receptor Research, San Francisco, USA
- Duties
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2023-Neuroscience representative on the Board of the BioHealth Department of Univ. Montpellier
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2015-2023Scientific Board member of France Alzheimer association
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2005-2010Elected member of the IGF Unit Council
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1997-Member of the International Society for Serotonin Research (ISSR)
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1997-Member of the French Neuroscience Society
- Editing
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2020-Associate editor for Frontiers in Aging Neuroscience,
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2019-Review editor for F. in Neuroscience & F. in Endocrinology
SKILLS / EXPERTISE
- My areas of expertise cover neuropharmacology, G-protein coupled receptors (GPCRs), serotonin receptors and neurodegenerative diseases. In connection with a network of clinicians, chemists, and biotech companies I propose innovative strategies to cure Alzheimer's disease (α-secretase activation, Multi-Targeted drugs, biomarkers), based on a deep knowledge of molecular and cellular mechanisms induced by GPCRs in neuroprotection.
- Member of the Inserm cross-cutting Program Microbiota, I currently explore the potential of gut microbiota modulation as a new therapeutic avenue against Alzheimer's disease.
Philippe
Coubes
IGF Sud 224 04 34 35 92 15Know more >
Philippe
Coubes
PU-PH1, UM
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Laurent
Givalois
IGF Sud 219 04 34 35 92 23Know more >
Laurent
Givalois
CRCN, CNRS
Team: Philippe Marin
EDUCATION
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2024Habilitation to Direct Research (HDR) - Université Laval - Québec - Canada
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1995PhD in Physiology - Neuroendocrinology - University of Montpellier - France
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1991DEA (Master's Degree Equivalent) in Adaptation and Survival in Extreme Environments - Claude Bernard University - Lyon - France
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1990Master's Degree in Pharmacology and Physiology - University of Montpellier - France
POSITIONS HELD
-
2025-CNRS Research Scientist - Institute of Functional Genomics (IGF) - Montpellier - France
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2020-Associate Professor - Laval University - Faculty of Medicine, Department of Psychiatry and Neurosciences - Québec, Canada
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2017-2024CNRS Research Scientist - Head of Team "Environmental Impact on Alzheimer’s Disease" (EiAlz) - Molecular Mechanisms in Neurodegenerative Dementias (MMDN), U1198 Inserm - Montpellier - France
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2009-2013Co-Founder and Member of the Scientific Advisory Board of the startup AMYLGEN - Montpellier - France
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2005-2016CNRS Senior Research Scientist (CR1) - Molecular Mechanisms in Neurodegenerative Dementias (MMDN), U710/U1198 Inserm - Montpellier - France
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2004-2005CNRS Senior Research Scientist (CR1) - Brain Plasticity Laboratory, UMR 5102 CNRS - Montpellier - France
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2000-2004CNRS Junior Research Scientist (CR2) - Brain Plasticity Laboratory, UMR 5102 CNRS - Montpellier - France
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1999-2000Postdoctoral Fellow - Brain Plasticity Laboratory, UMR 5102 CNRS - Montpellier - France
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1997-1999Temporary Lecturer and Researcher (ATER) - University of Montpellier - Brain Plasticity Laboratory, UMR 5102 CNRS - Montpellier - France
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1995-1997Postdoctoral Fellow - Molecular Endocrinology Laboratory - Laval University Hospital Center - Québec - Canada
HONORS / RESPONSABILITIES
- Awards
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2023-2025CNRS Individual Research Award
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2002Independent Investigator Award - NARSAD (The Brain & Behavior Research Foundation) - New York - USA
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2001Young Researcher Award - University of Montpellier - France
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2000Young Investigator Award - NARSAD - New York - USA
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1999Naturalia Biologica Prize from the French Academy of Sciences - France
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1999Young Researcher Award from the Society of Experimental Neuroendocrinology (SNE) - France
- Responsibilities
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2025-2027Member of the Executive Board and Treasurer of the French Society of Experimental Neuroendocrinology (SNE)
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2021-2024Member of the Scientific Council and Deputy Treasurer of the French Society of Experimental Neuroendocrinology (SNE)
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2018-2021Member of the Scientific Council of the French Society of Experimental Neuroendocrinology (SNE)
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2017-presentCo-Founder and Member of the Organizing Committee of the Alzheimer’s Club of Montpellier (CALM) - France
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2015-2024Member of the SBEA of the University of Montpellier (CECEMA)
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2005-2017Elected Member of the Council of the Laboratory of Molecular Mechanisms in Neurodegenerative Dementias (MMDN) - Montpellier
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2004-2008Elected Member of the Council of the Biology-Health Department - University of Montpellier
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2000-2008Elected Member of the Scientific Council and Board of Directors - University of Montpellier
SKILLS / EXPERTISE
- I am a neurobiologist and neuroendocrinologist specializing in the study of brain mechanisms. My work is based on an integrative approach that combines behavioral and electroencephalographic techniques with pharmacological, photopharmacological, biochemical, and immunohistochemical analyses.
- My research focuses on characterizing the roles and therapeutic potential of specific modulators of glucocorticoid, glutamate (mGlu5), and serotonin (5-HT6) receptors. These studies aim to enhance understanding and develop innovative therapeutic approaches to combat Alzheimer’s disease, while also addressing associated conditions such as chronic stress and epilepsy.
Marie-Laure
Parmentier
IGF Sud 225 04 34 35 93 19Know more >
Marie-Laure
Parmentier
DR2, Inserm
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Éric
Thouvenot
IGF Sud 221 04 34 35 92 13Know more >
Éric
Thouvenot
PU-PH1, UM
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Julien
Villeneuve
IGF Sud 225 04 34 35 93 19Know more >
Julien
Villeneuve
CRCN, CNRS
Team: Philippe Marin
EDUCATION
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2023Accreditation to supervise research (HDR) - University of Montpellier - France
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2008PhD in Biomedicine - Victor Segalen University - Bordeaux - France
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2005Master in Genetics - Victor Segalen University - Bordeaux - France
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2003Maîtrise in Physiology - Poitiers University, France
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2002Licence in Cellular Biology and Physiology - Poitiers University - France
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2001DEUG in Biology - La Rochelle University - France
POSITIONS HELD
-
2020-Permanent Researcher (CRCN) at CNRS - Institute for Functional Genomics (IGF) - Montpellier - France
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2018-2020Research Associate - University of Cambridge - UK
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2016-2017Postdoctoral fellow - Center for Genomic Regulation (CRG) - Barcelona - Spain
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2014-2016Postdoctoral fellow - University of California Berkeley - USA
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2010-2013Postdoctoral fellow - Center for Genomic Regulation (CRG), Barcelona, Spain
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2008-2009Postdoctoral fellow, INSERM U889 - Victor Segalen University - Bordeaux - France
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2005-2008PhD student, INSERM U889, Victor Segalen University - Bordeaux - France
HONORS / RESPONSABILITIES
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2019Marie Curie Standard European Postdoctoral fellowship (IF-EF-ST)
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2014Marie Curie International Outgoing Postdoctoral fellowship (IOF)
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2010EMBO Long-Term Postdoctoral fellowship
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2009FRM Postdoctoral fellowship
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2008AFEF Postdoctoral fellowship
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2005MRT PhD fellowship
SKILLS / EXPERTISE
- My research projects are mainly focused on understanding the basic mechanisms underlying inter- and intracellular communication, in order to determine how their deregulation may be associated with the development of various pathologies.
- Briefly, in the course of my career, which started at the University of Bordeaux, followed by the Centre for Genomic Regulation in Barcelona, the University of California at Berkeley and finally the University of Cambridge, I have developed fundamental and translational research projects that have enabled me to acquire solid expertise in the fields of intracellular trafficking and protein secretion, thanks in particular to my training in the laboratories of Prof Randy Schekman and Dr Vivek Malhotra. In their laboratories, I identified new factors involved in conventional and unconventional secretion and discovered processes essential to the organisation and dynamics of intracellular compartments. I also worked in collaboration with Dr Jonathan Weissman at the University of California, San Francisco (UCSF) on the development of a pooled genome-wide CRISPRi screen to identify new factors essential for protein transport and secretion. More recently, I worked in the laboratory of Prof David Rubinsztein at the University of Cambridge, where I studied the development of neurodegenerative diseases associated with the accumulation and dissemination of toxic misfolded proteins.
- Today, as a CNRS researcher since November 2020, I am developing projects on fundamental mechanisms at the interface between membrane trafficking and the unconventional secretion of misfolded proteins, with the objective of developing new biomedical applications for the treatment and prevention of neurodegenerative diseases.
Technicians and engineers
Sonya
Galant
IGF Sud 221 04 34 35 92 13Know more >
Sonya
Galant
IECN, CNRS
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Magali
Lançon
IGF Sud 204 04 34 35 92 16Know more >
Magali
Lançon
TCE, UM
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Postdoctoral researchers and doctoral students
Léo
Boussamet
IGF Sud 224 04 34 35 92 15Know more >
Léo
Boussamet
Chercheur CDD, CNRS
Team: Philippe Marin
EDUCATION
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2024Doctorate - Immunology - Nantes University - France
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2020Master - Bioinformatics - Nantes University - Nantes - France
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2017Master – Public Health - OnirisVetAgroBio - Nantes - France
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2015Bachelor's degree - Biology Biochemistry – Nantes University – Nantes - France
POSITIONS HELD
-
2025-Post-doctorate (Dir. S. Claeysen) - Institute of Functional Genomics - Montpellier - France
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2020-2024Thesis (Dir. L. Berthelot) – Center for Research in Transplantation and Translational Immunology - Nantes - France
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2020Master 2 internship – umr1064 – metagenomics study in multiple sclerosis – Nantes – France
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2019Master 1 internship – umr1064 – metagenomics study in gut inflammatory diseases – Nantes – France
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2017Project manager R&D nutrition – Biolait SAS – piloting dairy fatty acid content – Saffré - France
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2017Master 2 internship – umr703 – Development of a platelet lysate-based culture medium for a candidate cell therapy vector – Nantes - France
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
- I work at the interface between biology and data science, specializing in metagenomics, immunology and neuroinflammation. My research interests include:
- The discovery of diagnostic and prognostic biomarkers from transcriptomic, proteomic and metagenomic data
- Identifying therapeutic targets and underlying pathological mechanisms
- Main techniques mastered
- Cultures of cell lines
- Molecular biology: PCR, qPCR, Western Blot, DNA/RNA extractions
- Immunohistochemistry
- Data analysis
- R, Python, Bash, C programming
- Biostatistics
- Image J
- High performance computing (SLURM, SGE)
Thomas
Curel
IGF Sud 224 04 34 35 92 15Know more >
Thomas
Curel
Doctorant(e), Inserm
Team: Philippe Marin
EDUCATION
-
2021Master's degree in Biology-Health, specializing in Neuroscience - University of Montpellier - France
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2019Bachelor's degree in Life Sciences - University of Montpellier - France
POSITIONS HELD
-
2021-PhD fellow - Institute of Functional Genomics (IGF) - Montpellier - France
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2021Master 1 internship (Dir. ML. Parmentier) - Institute of Functional Genomics - Montpellier - France
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2020Master 2 internship - Amylgen Company- Montpellier - France
HONORS / RESPONSABILITIES
-
2022-2023Member of IGF doctoral and postdoctoral student network
SKILLS / EXPERTISE
- I'm a biologist specializing in neuroscience. My research interests revolve around signaling in brain pathologies and innovative therapeutic strategies.
- Main techniques
- Molecular biology: protein extraction and assay, Western blot, ELISA, pharmacology
- Imaging: immunohistochemistry, immunofluorescence, epifluorescence and confocal microscopy
- Data analysis: GraphPad Prism, Jamovi, pack office, Image J, Cell Profiler
Soufiane
El Khayari
IGF Sud 220 04 34 35 92 13Know more >
Soufiane
El Khayari
Doctorant(e), UM
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Marylou
Grasso
IGF Sud 215 04 34 35 92 42Know more >
Marylou
Grasso
Doctorant(e), CHU
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Eloise
Neel
IGF Sud 225 04 34 35 93 19Know more >
Eloise
Neel
Doctorant(e), CNRS
Team: Philippe Marin
EDUCATION
-
2021-2023Master - Health & Biology - University of Montpellier - France
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2018-2021Licence – Science of Life - University of Bordeaux - France
POSITIONS HELD
-
2023-Thesis (Dir. M-L. Parmentier, J. Villeneuve) – Institute of Functional Genomics – Montpellier - France
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
- Main techniques mastered
- - Molecular biology: Western blot, immunoprecipitation, mass spectrometry
- - Cell line cultures
- - Working in the BSL2 sector
- - Microscopy
- Data analysis
- - GraphPad Prism
- - Mastery of Pack office
- - Image J/FIJI
Clemence
Quittet
IGF Sud 221 04 34 35 92 13Know more >
Clemence
Quittet
Doctorant(e), UM
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Manon
Rival
IGF Sud 221 04 34 35 92 13Know more >
Manon
Rival
Doctorant(e), Inserm
Team: Philippe Marin
EDUCATION
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2023Inter university degree – Myelin diseases – Sorbonne university– France
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2023Diploma of specialized studies - Neurology - University of Montpellier- France
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2022Doctorate - Medicine - University of Montpellier- France
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2022Master - Health & Biology - University of Montpellier- France
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2020Inter university degree – Migraine and headaches - University of Montpellier- France
POSITIONS HELD
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2024-Thesis (Dir. E. Thouvenot, P.Marin) - IGF - Montpellier - France
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2023-2023Head of clinic of the Universities, Assistant – CHU Nimes - Nimes - France
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2022Internship (8 months) - IGF - Montpellier - France
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2018-2023neurology residency – University of Montpellier- France
HONORS / RESPONSABILITIES
- Distinctions
-
2024-2027Fondation pour le Recherche Médicale Fellowship
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2024ARSEP Fellowship
- Duties
-
2025Poster Prize P234 « High-dose cholecalciferol reduces multiple sclerosis disease activity after a clinically isolated syndrome : results of a 24-months placebo-controlled randomized trial” - JNLF Congress – Clermont Ferrand – France
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2025Poster Prize P15 « Impact of Syndecan1-CHI3L1 interaction on myelination mechanisms” - France SEP Congress – Paris – France
SKILLS / EXPERTISE
- Main techniques mastered
- Cultures of cell lines
- Molecular biology: Western Blot, Extraction biochemical tests
- Immunochemistry, microscopy
- Work in BSL2 sector
- Data analysis
- GraphPad Prism
- Mastery of Pack office
- Image J
- RNA-Seq
- transcriptome
Mehdi
Sekssaoui
IGF Sud 224 04 34 35 92 15Know more >
Mehdi
Sekssaoui
Doctorant(e), Inserm
Team: Philippe Marin
EDUCATION
-
2021Master's Degree in Neurosciences - University of Montpellier - France
-
2019Bachelor's Degree in Neurosciences and Animal Physiology - University of Montpellier - France
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2018DUT in Biological Engineering, option Biological and Biochemistry Analyses - IUT of Montpellier - France
POSITIONS HELD
-
2021-PhD student (Dir. C. Bécamel, Marin Team) - Institute of Functional Genomics (IGF) Montpellier - France
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2020-2021Master 2 internship (6 months, Marin Team) - Institute of Functional Genomics (IGF) - Montpellier - France
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2019-2020Master 1 internship (5 months, Bourinet Team) - Institute of Functional Genomics (IGF) - Montpellier - France
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2017-2018DUT internship(2 months, Vision Team) - Institute of Neurosciences of Montpellier (INM) - Montpellier - France
HONORS / RESPONSABILITIES
-
20212nd at the CBS2 Doctoral School competition of Montpellier
SKILLS / EXPERTISE
- I'm a PhD student working on preclinical models of psychiatric pathologies. My projects focus mainly on depression and schizophrenia. My expertise revolves around 3 components:
- Behavioral studies
- Electrophysiology
- Acute slices of prefrontal cortex and dorsal raphe (dissection, vibratome sectioning)
- Electrophysiological studies on these slices: study of intrinsic neuronal properties and synaptic transmission (spontaneous and miniature currents).
- Biochemical analysis
- Western blot and ELISA analysis of tissue shreds
- Purification of synaptosomes and pre/post synaptic compartments
- Complementary techniques
- Immunofluorescence
- RNA Scope
- Molecular biology (PCR)
- GraphPad Prism, Pack Office, Image J, Cell Profiler
Charleine
Zussy
IGF Sud 219 04 34 35 92 23Know more >
Charleine
Zussy
Chercheur CDD, UM
Team: Philippe Marin
EDUCATION
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2006-2009Doctorate - Health & Biology - University of Montpellier - France
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2004-2006Master - Health & Biology - University of Montpellier - France
POSITIONS HELD
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2025-Researcher CDD (Dir. L. Givalois) - IGF - University of Montpellier - France
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2020-2025Researcher CDD (Dir. L. Givalois) - MMDN - University of Montpellier - France
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2017-2019Post-doctorate (Dir. C. Desrumaux) - MMDN - University of Montpellier - France
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2013-2016Post-doctorate (Dir. C. Goudet) - Institute of Functional Genomics (IGF) - Montpellier - France
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2010-2013Post-doctorate (Dir. E. Kremer) - Institute of Molecular Genetics of Montpellier (IGMM) - Montpellier - France
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2006-2009Thesis (Dir. L. Givalois) - University of Montpellier - France
HONORS / RESPONSABILITIES
- Distinctions
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2017Young researchers Prize - French Society for the Study and Treatment of Pain
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2017Young researchers Prize - Major Advances in Biology-Health
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2016Grünenthal Prize - fundamental research category against pain
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2006PhD Fellowship MENRT
SKILLS / EXPERTISE
- I am a neurobiologist. By combining approaches such as photopharmacology, EEG recording, behavioral and biochemical analyses, I have developed research projects aimed at characterizing the impact of the frequency of modulation of synaptic receptors (e.g. mGlu5, A2A, NMDA… ) in the hippocampus on markers of Alzheimer's disease (cognitive deficits, neuroinflammation, senile plaques, hyperphosphorylation of tau, etc.).
- I also use this expertise to study the link between Alzheimer's disease and epilepsy as well as the impact of selective modulators of glucocorticoid receptors to block these pathologies.
Fixed term contract technicians and engineers
Ophélie
Bento
IGF Sud 224 04 34 35 92 15Know more >
Ophélie
Bento
IE CDD, CNRS
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Morgane
Denus
IGF Sud 225 04 34 35 93 19Know more >
Morgane
Denus
IE CDD, CNRS
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
William
Fargues
IGF Sud 225 04 34 35 93 19Know more >
William
Fargues
IE CDD, CNRS
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Magalie
Mathias
IGF Sud 219 04 34 35 92 23Know more >
Magalie
Mathias
IE CDD, UM
Team: Philippe Marin
EDUCATION
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2018-2019MSc - Health Biology, Experimental and Regenerative Medicine - University of Montpellier - France
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2016-2017Bachelor's degree in Animal Physiology and Neurology - Health Biology - University of Montpellier - France
POSITIONS HELD
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2022-Study engineer (Dir. L. Givalois) - University of Montpellier - France
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2018-2019Master 2 internship (Dir. N. Gayrard) - RD Nephrology - France
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2017-2018Master 1 internship (Dir. F. Ango) - Institute of Functional Genomics - Montpellier - France
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
- Main techniques mastered
- Immunohistofluorescence
- Culturing cell lines (HEK, ...)
- Molecular biology: Western blot, extraction & biochemical tests, genotyping
- Microtome cutting, cryostat, vibratome
- Data analysis
- Proficiency in Pack Office
- LastX
- Image J
Trainees
Lohan
Andreoli
IGF Sud 225 04 34 35 93 19Know more >
Lohan
Andreoli
Master 1, CNRS
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Candice
Dieu
IGF Sud 221 04 34 35 92 10Know more >
Candice
Dieu
Master 2, UM
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Jeanne
Mouda
IGF Sud 224 04 34 35 92 15Know more >
Jeanne
Mouda
Master 2, Inserm
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
Clara
Zirah
IGF Sud 219 04 34 35 92 15Know more >
Clara
Zirah
Master 2, CNRS
Team: Philippe Marin
EDUCATION
POSITIONS HELD
HONORS / RESPONSABILITIES
SKILLS / EXPERTISE
- Philibert CE, Disdier C, Lafon PA, Bouyssou A, Oosterlaken M, Galant S, Pizzoccaro A, Tuduri P, Ster J, Liu J, Kniazeff J, Pin JP, Rondard P, Marin P*, Vandermoere F*. TrkB receptor interacts with mGlu2 receptor and mediates antipsychotic-like effects of mGlu2 receptor activation in the mouse. Sci Adv. 2024 Jan 26;10(4):eadg1679. doi: 10.1126/sciadv.adg1679. PMID: 38277461.
- Hinsinger G, Du Trieu de Terdonck L, Urbach S, Salvetat N, Rival M, Galoppin M, Ripoll C, Cezar R, Laurent-Chabalier S, Demattei C, Agherbi H, Castelnovo G, Lehmann S, Rigau V, Marin P, Thouvenot E. CD138 as specific CSF biomarker of multiple sclerosis Neurol Neuroimmunol Neuroinflamm. 2024 May;11(3):e200230. doi: 10.1212/NXI.0000000000200230, PMID: 38669615
- Sekssaoui M, Bockaert J, Marin P*, Bécamel C*. Antidepressant-like effects of psychedelics in a chronic despair mouse model: is the 5-HT2A receptor the unique player? Neuropsychopharmacology 2024 Jan 11. doi:10.1038/s41386-024-01794-6. PMID: 38212441.
- Sengupta S, Mondal M, Prasasvi KR, Mukherjee A, Magod P, Urbach S, Friedmann- Morvinski D*, Marin P*, Somasundaram K*. Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth. Elife 2022 Jun 1;11:e78972. doi:10.7554/eLife.78972. PMID: 35642785.
- Sheu SH, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, Walpita D, Pasolli HA, Houser J, Sanchez-Martinez S, Brauchi SE, Banala S, Freeman M, Xu CS, Kirchhausen T, Hess HF, Lavis L, Li Y, Chaumont-Dubel S, Clapham DE. A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell 2022 Sep 1;185(18):3390-3407.e18. doi:10.1016/j.cell.2022.07.026. PMID: 36055200.
- Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, Séveno M, DurrouxT, Junier MP, Schlecht-Louf G, Bachelerie F, Schütz D, Stumm R, Smit MJ, Guérineau NC, Chaumont-Dubel S, Marin P. The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication. Nat Commun. 2020 Sep 25;11(1):4855. doi: 10.1038/s41467-020-18634-y. PMID: 32978390.
- Berthoux C, Hamieh AM, Rogliardo A, Doucet EL, Coudert C, Ango F, Grychowska K, Chaumont-Dubel S, Zajdel P, Maldonado R, Bockaert J, Marin P*, Bécamel C*. Early 5-HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse. EMBO Mol Med. 2020 May 8;12(5):e10605. doi:10.15252/emmm.201910605. Epub 2020 Apr 24. PMID: 32329240.
- Pujol CN, Dupuy V, Séveno M, Runtz L, Bockaert J, Marin P*, Chaumont-Dubel S*. Dynamic interactions of the 5-HT6 receptor with protein partners control dendritic tree morphogenesis. Sci Signal. 2020 Feb 11;13(618):eaax9520. doi: 10.1126/scisignal.aax9520. PMID: 32047117.
- Rochais C, Lecoutey C, Hamidouche K, Giannoni P, Gaven F, Cem E, Mignani S, Baranger K, Freret T, Bockaert J, Rivera S, Boulouard M, Dallemagne P, Claeysen S. Donecopride, a Swiss army knife with potential against Alzheimer’s disease. Br J Pharmacol. 2020 May;177(9):1988-2005. doi: 10.1111/bph.14964. PMID: 31881553.
- Murat S, Bigot M, Chapron J, König GM, Kostenis E, Battaglia G, Nicoletti F, Bourinet E, Bockaert J, Marin P*, Vandermoere F*. 5-HT2A receptor- dependent phosphorylation of mGlu2 receptor at Serine 843 promotes mGlu2 receptor-operated Gi/o signaling. Mol Psychiatry. 2019 Nov;24(11):1610-1626. doi: 10.1038/s41380-018-0069-6. PMID: 29858599.
Microbiota, serotonin and neurodegenerative diseases
Principal investigator
Sylvie CLAEYSEN
GPCR signaling, compartmentalization and pathophysiological roles
Principal investigator
Séverine CHAUMONT-DUBEL
Protein trafficking and neurodegenerative diseases
Principal investigator
Julien VILLENEUVE
Identification and functional analysis of multiple sclerosis biomarkers
Principal investigator
Eric THOUVENOT
Normal and pathological functions of Tau / Eco-emotions and mental health
Principal investigator
Marie-Laure PARMENTIER
Regulations and signaling of metabotropic glutamate receptor mGlu2, the target of a new generation of antipsychotics
Principal investigator
Franck VANDERMOERE
PhD students
Lucie PELLISSIER
2004 – 2009
CRCN CNRS, Tours, France – ERC Starting Grant 2019 –CNRS Bronze Medal 2022
Gaëlle CARRAT
2007 – 2010
Clinical Research Associate, Medpace, Londres, Angleterre, Royaume-Uni
Julie MEFFRE
2007 – 2011
Postdoc, LNC, Marseille, France
Samah KARAKI
2008 – 2011
Founder of the Social Brain Institute, Paris, France
Maud COCHET
2007 – 2011
Pedagogical coordinator Lyon, France
Alexander BARRE
2009 – 2013
Patch Clamp engineer, Neuroservices, Aix en Provence, France
Romain DONNEGER
2010 – 2014
Lead Clinical Operations, Roche, Paris, France
Fanny DUHR
2011 – 2015
MD, France
Geoffrey HINSINGER
2013 – 2016
Psychiatric intern, AP-HM, Marseille, France
Coralie BERTHOUX
2013 – 2017
Staff scientist, Albert Einstein College of Medicine, NY, USA
Camille PUJOL
2014 – 2018
Psychiatric intern, CHRU Strasbourg, France – Madeleine Lecoq Award from Académie des Sciences 2022
Samy MURAT
2014 – 2018
Intern in Geriatrics, CHU Nîmes, France
Amos FUMAGALLI
2015 – 2019
Postdoc The Netherlands Cancer Institute, Amsterdam, Netherlands – Recipient of 2 bourses Marie Curie
Bérénice HATAT
2016 – 2019
Odontology student, Montpellier, France
Hugo PAYAN
2016 – 2020
Postdoc, Duke-NUS Medical School, Singapour
Angelina ROGLIARDO
2017 – 2021
Postdoc, INM, Montpellier, France
Vincent DUPUY
2017 – 2021
Postdoc, IINS, Bordeaux, France
Caroline ISMEURT
2017 – 2021
Postdoc, IGMM, Montpellier, France
Lucile DU TRIEU DE TERDONCK
2017 – 2021
Postdoc, INP, Marseille, France
Clémentine PHILIBERT
2018 – 2022
Postdoc, Boston University School of Medicine, Boston, USA
Ophélie BENTO
2020 – 2023
Postdoc, IGF, Montpellier, France
Manon GALOPPIN
2020 – 2023
Postdoc, PhyMedExp, Montpellier, France
Alessandro RABBITO
2020 – 2024
Postdoc, USA
Lucy KUNDURA
2023 – 2024
R&D project manager, Ciloa, Montpellier, France
Tomas DEL OLMO
2020 – 2025
Postdoc IGH, Montpellier, France
Post-doctoral fellows
Elena MARCELLO
2011 – 2012
Associate Professor, Univ. Milano, Italy
Paul DELERIS
2012 – 2014
Associate Professor, Univ. Nantes, France
Pascal SEYER
2012 – 2015
Associate Professor Univ. Montpellier, France
Patrizia GIANNONI
2011 – 2016
Associate Professor, Univ. Nîmes, France
Al Mahdy HAMIEH
2015 – 2016
Clinical and preclinical studies manager, Virbac, PACA, France
Simon NICOT
2017 – 2018
Post-doc EFS, Montpellier, France
Émilie DOUCET
2016 – 2020
Laboratory Manager Nervosave Therapeutics, Montpellier, France
Clinical studies conducted by the team
MICMALZ – Analysis of the microbiota’s blood signature as a diagnostic marker for Alzheimer’s disease in its early stages: Pilot study
S. Claeysen (IGF) / A. Gabelle & K. Bennys (CMRR, CHU Montpellier)
The aim of this study is to characterize the composition of the microbiota, in stool and blood, of patients with Alzheimer’s disease (AD, Alzheimer’s group) and people with memory complaints unrelated to AD (Control group). Participants without memory defects are also included in the study (Neurotypical group).
To date, we have included 116 subjects and are continuing recruitment for the Neurotypical group.
D-Lay MS – Efficacy of Cholecalciferol (Vitamin D3) for Delaying the Diagnosis of MS After a Clinically Isolated Syndrome
E. Thouvenot (IGF, CHU Nîmes)
This is the largest randomized, double-blind clinical trial to assess the clinical efficacy of high-dose vitamin D versus placebo in reducing multiple sclerosis (MS) activity after a first clinical attack of the disease.
In 35 centers in France, we included 316 patients followed for two years and studied the impact of vitamin D on the clinical and MRI evolution of MS.
VDSS – Peripheral Immunological Effects of High-dose Vitamin D Treatment in Healthy Subjects
E. Thouvenot (IGF, CHU Nîmes)
The aim of this study was to clarify the immunomodulatory effects of Vitamin D (3 months treatment with cholecalciferol 100,000 IU) on lymphocytes from healthy subjects, to establish a normal regulatory profile and thus define potential pathological regulations in MS patients included in D-Lay MS. To this end, we randomized 56 healthy subjects to vitamin D or placebo for 3 months and collected blood samples (PBMC) at inclusion and at 3 months.
We also took stool samples at 3 months to characterize the composition of the microbiota, in stool and blood, of healthy subjects, to study the effects of vitamin D and to serve as a reference for other studies by the team.
