Team Stéphane DALLE – Eric RENARD
Innovative therapeutics for diabetes
Project Mechanisms of beta-cell alteration: involvement of amyloidogenic proteins and pesticides
PRINCIPAL INVESTIGATOR
IGF staff involved
Magalie RAVIER
CRHC INSERM
Ambrine ARRAR
PhD Student INSERM
This research group is interested in identifying the mechanisms by which beta-cells are altered in response to proteotoxic and/or environmental stresses. To this end, insulin-secretory function, survival and the integrity of protein degradation pathways (autophagy, ubiquitin-proteasome system) are assessed in beta-cell lines and pancreatic islets (murine and human) using a combination of cell/molecular biology and imaging techniques.
More specifically, the current project aims to assess the impact of chronic exposure to a mixture of low doses of pesticides on the onset of type 2 diabetes and Parkinson’s disease, and to identify possible common mechanisms of alteration between these two pathologies. Developed in collaboration with INRAE and ANSES, this project is conducive to the identification of new strategies – both therapeutic and preventive – aimed at protecting beta-cells.
Potential mechanistic links between Parkinson’s disease and type 2 diabetes
Main publications
• Brown MR., et al. (2022) Cell Death Dis, 13(4), 353.
• Costes S., et al. (2021) Int J Mol Sci, 22(10), 5303.
• Costes S. (2018) Curr Opin Pharmacol, 43,104-110.
• Ruiz L., et al. (2018) Cell Death Dis, 9(6), 600.
Funding
• 2025-2029 : ANR 2024-Bastion – Partner
• 2025-2028 : Fellowship France Parkinson (A. Arrar)
• 2023 : Gilberte et Jacques Tacussel Award from the National Academy of Medicine – Laureate
• 2022-2025 : ANSES – DEEP project – Coordinator
• 2022-2025 : French Society of Diabetes – Coordinator
Collaborations
• Thierry Baron (Lyon)
• Aleksey Matveyenko (Rochester, USA)
• Laurence Payrastre (Toulouse)
• Etienne Blanc (Paris)
• Human Cell Design
• Christophe Broca, Julia Sabatier (Human islet isolation platform, Montpellier)
Alumni
• Nour Mesto (post-doc)
