Team Stéphane DALLE – Eric RENARD
Innovative therapeutics for diabetes
Project Automated insulin delivery by wearable or implantable systems
PRINCIPAL INVESTIGATOR
IGF staff involved
Orianne VILLARD
CC-AH University of Montpellier
Anne FARRET
PH, Montpellier University Hospital
This project aims at providing an insulin supply closer to physiology for the treatment of type 1 diabetes through automated insulin delivery using control algorithms which modulates insulin infusion from wearable or implantable pumps based upon continuous glucose monitoring by electro-enzymatic sensors inserted in the interstitial milieu. The research team evaluates the safety and efficacy of closed-loop systems on glucose control and improvement of users’ quality of life.
The safety and efficacy of automated insulin delivery systems on blood glucose control in type 1 diabetes is assessed by clinical trials in various populations living with type 1 diabetes: children and adolescents with recent diagnosis, people with high risk of hypoglycemia, people with high blood glucose variability.
Current projects include :
- Assessment of the efficacy of automated insulin therapy (‘artificial pancreas’) early initiated after diagnosis on blood glucose control in children and adolescents with type 1 diabetes : randomized comparison with a conventional insulin therapy for 1 year, followed by an optional extension for 1 year (AP-AT-DIAGNOSIS).
- Improving Type 1 Diabetes Treatment Through Unobtrusive Continuous Diabetes Management Technology (MuSiC4Diabetes).
- A bionic invisible pancreas to forget diabetes (FORGETDIABETES).
Automated insulin delivery systems : A. OmniPod 5 assessed in the project AP-AT-DIAGNOSIS ; B. System developed in the project MuSiC1Diabetes.
Main publications
• Reznik Y., et al. (2024) Diabetes Obes Metab, 26, 622
• Renard E., et al (2023) Diabetes Care, 46, 2180
• Coutant R., et al. (2023) Diabetes Technol Ther, 25, 395
• Renard E., et al. (2022) Diabetes Obes Metab, 24, 511
• He J., et al. (2022) J Control Release, 341, 487
Funding
• 2023-2027 : MuSiC4Diabetes – HORIZON-EIC-2022-PATHFINDERCHALLENGES-01 – Partenaire
• 2022- 2027 : AP-AT-DIAGNOSIS –PHRC 2021 – Coordinateur
• 2020-2025 : FORGETDIABETES – HORIZON 2020-EIC-FETPROACT-2019 – Partenaire
Collaborations
• Claudio Cobelli (Padoue)
• Marc Breton (Charlottesville)
• Boris Kovatchev (Charlottesville)
• Martin Richter (Munich)
