Thesis – Manon MARROT

Pathophysiological remodeling of cardiac rhythm in aging 

Jury

• Isabelle Baro, DR-Inserm – Institut du Thorax – Nantes, Reviewer
• Flavien Charpentier , DR-Inserm – Institut du Thorax – Nantes, Reviewer
• Florence Perrin, PU-Université Montpellier – Montpellier, Examiner
• Delphine Mika, CR-Inserm , Lab Signalisation et Physiopathologie Cardiovasculaire – Orsay, Examiner
• Angelo Parini, PU1, PUPH, Institut des Maladies Métaboliques et Cardiovasculaires – Toulouse, Examiner
• Stéphanie Barrère-Lemaire, DR-CNRS, Institut de Génomique Fonctionnelle – Montpellier, Thesis director
• Matteo Elia Mangoni, DR-CNRS, Institut de Génomique Fonctionnelle – Montpellier, Thesis co-director
• Angelo Giovanni Torrente, CR-CNRS, Institut de Génomique Fonctionnelle – Montpellier, Thesis co-supervisor
• Nadine Mestre-Francès, DE EPHE, Mécanismes Moléculaires dans les Démences Neurodégénératives – Montpellier, Guest

Summary

Cardiovascular diseases represent the leading cause of death worldwide. Due to the increasing ageing of the population, their incidence will increase in the coming decades, creating a major public health problem. Among these diseases, several cardiac rhythm disorders are found in the elderly. To date, the mechanisms involved remain poorly understood. Aim: To study the consequences of ageing on cardiac activity in the mouse and lemur models, in order to develop cardioprotective strategies, delaying cardiac dysfunctions in elderly individuals. Methods: Recording (i) ECGs with telemetry and tunnel ECG systems ELISA and (ii) apoptotic proteins with Western Blot. Conclusion: In the mouse model, this thesis work has highlighted a decline in intrinsic pacemaker activity of the sinus node, particularly in the β-adrenergic response with ageing. Similarly, in the lemur model, particularly in males, this thesis work suggests sympathetic incompetence and diastolic dysfunction during ageing.