Lieu: IGF SUD Salle Pierre Soulages | Ville: Montpellier, France
CHLORIDE CHANNELS : permeable to Cl- ions but not only...
CHRISTOPHE DURANTON
CNRS-UMR 7370 - Laboratoire de Physio-médecine moléculaire Nice
Cl- ion channels have always been underestimated principally due to the difficulties to characterize their molecular identities and by the absence of specific inhibitors. A growing number of evidences suggest that chloride channels dynamically regulated intracellular chloride concentration and play a crucial role in the transmission of cellular signals by controlling oxidative stress level. In this seminar, I will summarize recent advances concerning 2 different chloride channels: CFTR and the VRAC/LRRC8. and their abilities to transport chloride ions but more surprisingly other substrates such as glutathione or ATP. I will also describe our latest findings identifying these 2 chloride channels as major actors in the control of cell destiny and the regulation of oxidative stress level.
Propulsé par iCagenda
Évènements
Lun | Mar | Mer | Jeu | Ven | Sam | Dim |
---|---|---|---|---|---|---|
1
|
2
|
3
| ||||
4
|
5
|
6
|
7
|
8
|
9
|
10
|
11
|
12
|
13
|
14
|
15
|
16
|
17
|
18
|
19
|
20
|
21
|
23
|
24
| |
25
|
26
|
27
|
28
|
29
|
30
|