Lieu: Genopolys | Ville: Montpellier, France
CANNABINOID-INDUCED ACTOMYOSIN CONTRACTION SHAPES NEURONAL STRUCTURE AND CONNECTIVITY AT MULTIPLE SPATIOTEMPORAL SCALES
Zsolt LENKEI
(ESPCI Paris)
We have recently shown rapid cannabinoid-induced remodeling of the neuronal actomyosin cytoskeleton with potentially important roles in developmental brain wiring. Our recent results indicate a role for cannabinoid-induced actomyosin contraction also in synaptic plasticity. Completing our in vitro and ex vivo tools, we participate in the interdisciplinary development of a new in vivo imaging modality, functional fast brain ultrasound (fUS), to investigate the role of cannabinoid-induced actomyosin contraction in the structure and connectivity of the living rodent brain. fUS offers fMRI-like functional imaging, both in anaesthetised and awake animals, with spatio-temporal resolution gains of several orders of magnitude as compared to fMRI.
Propulsé par iCagenda