NEURAL CIRCUITS AND VALUE CODING
Department : Neuroscience
Research subject
For additional information, please visit Team website
To survive, animals constantly compare and make choices between several options based on the value assigned to each option during past experience. During associative learning, absolute (good or bad) and/or relative (better or worse than) values can be assigned to each experience.
The main goal of the lab is to decipher how, in the fly brain, value (absolute and relative) are assigned to sensory stimuli during learning and later used to make appropriate value-based/economic decisions. To tackle such evolutionary-conserved brain processes, the lab is using the fruit fly Drosophila melanogaster as a model combined with sophisticated genetics, in vivo two-photon calcium imaging, molecular biology and behavioural analysis.
(on the left) A fly associating an odour and a punishment under a 2-photon microscope
(in the middle) GABAergic Mushroom body output neurons
(on the right) GABAergique and glutamatergique Mushroom body output neurons anatomical connectivity
Equipe ATIP-Avenir soutenue par La Fondation Bettencourt Schueller
Junior European Drosophila Investigator
Major publications
- Felsenberg J, Jacob PF, Walker T, Barnstedt O, Edmondson-Stait AJ, Pleijzier MW, Otto N, Schlegel P, Sharifi N, Perisse E, Smith CS, Lauritzen S, Costa M, Jefferis GSXE, Bock DD and Waddell S. (2018) Integration of Parallel Opposing Memories Underlies Memory Extinction. Cell 175, 1–14.
- Perisse E*, Owald D*, Barnstedt O, Talbot C, Huetteroth W and Waddell S. (2016) Aversive learning and appetitive motivation toggle feed-forward inhibition in the Drosophila mushroom body. Neuron, 90, 1-14.
- Huetteroth W, Perisse E, Klappenbach M, Burke CJ, Lin S and Waddell S. (2015) Separated representations of sweet taste and nutrient value in rewarding dopaminergic neurons in Drosophila. Curr Biol, 25, 1-18.
- Owald D, Felsenberg J, Das G, Perisse E, Talbot C, Huetteroth W, Waddell S. (2015) Activity of defined mushroom body output neurons underlies learned olfactory behavior in Drosophila. Neuron, 86, 1-11.
- Perisse E, Yin Y, Lin A, Lin S, Huetteroth W, Waddell S. (2013) Different Kenyon cell populations drive learned approach and avoidance in Drosophila. Neuron, 79, 945–956.
- Burke CJ, Huetteroth W, Owald D, Perisse E, Krashes MJ, Das G, Gohl D, Silies M, Certel S, Waddell S. (2012) Layered reward signalling through octopamine and dopamine in Drosophila. Nature, Dec 20;492(7429):433-7.
(*co-first author)