The Neuroscience Department comprises 12 teams whose research topics focus on the mechanisms that determine the functioning of the nervous system. The topics include molecular, cellular and integrated aspects of CNS physiology and pathology, including epilepsy, mental retardation, depression, anorexia/bulimia, pain, schizophrenia, and various neurodegenerative diseases, such as multiple sclerosis, Alzheimer's, Parkinson's and Huntington's diseases.
The historical strengths of the department (molecular & cellular analyses of receptors, ion channels, and of their signaling complexes) have been reinforced by the recruitment of new teams, with a strong know-how in behavior analyses and in vivo studies of CNS functions, and by the integration of clinicians in the department. We use several experimental models (cell cultures, drosophila, zebra fish, rats, mice), and a variety of methods (crystallography, cryo-EM, multi-omics approaches, optical methods, opto and chemogenetics, electrophysiology, behavior analysis), and we develop new tools (nanobodies, photo-switchable molecules) to bridge molecular/cellular knowledge with integrated functions of the CNS and identify new therapeutic targets and biomarkers of CNS diseases.

Coordinator : Étienne AUDINAT