Self-renewal and differentiation of epithelia
Research interests
We use the intestinal epithelium as a model to study the key properties of epithelia with rapid turnover, such as their function as an interface between the organism and the environment, and the diseases associated with alterations in these properties, including cancer and chronic inflammatory diseases.
Selected publications
Gerbe F., Legraverend C. and Jay P.: The intestinal tuft cells : specification and function.
Cell Mol. Life Sci. (2012) in press. Link
Ecobar M., Nicolas P., Sangar F., Laurent-Chabalier S., Clair P., Joubert D., Jay P. and Legraverend C. : Intestinal epithelial stem cells do not protect a copy of their genome by asymmetric chromosome segregation.
Nature Communications, 2 : 258 (2011). Link
Gerbe F., van Es J. H., Makrini L., Brulin B., Mellitzer G., Robine S., Romagnolo B., Shroyer N. F., Bourgaux J.-F., Pignodel C., Clevers H. and Jay P. : Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.
The Journal of Cell Biology, vol. 192(5) : 767-780 (2011). Link
Link to the Editorial comment on this article
Gerbe F., Brulin B., Makrini L., Legraverend C. and Jay P. : DCAMKL-1 expression identifies tuft cells rather than stem cells in the adult mouse intestinal epithelium.
Gastroenterology, vol. 137(6) : 2179-2180 (2009). Link
Bastide P., Darido C., Pannequin J., Kist R., Robine S., Marty-Double C., Bibeau F., Scherer G., Joubert D., Hollande F., Blache P. and Jay P. : Sox9 regulates cell proliferation ans is required for Paneth cell differentiation in the intestinal epithelium.
The Journal of Cell Biology, vol. 178 (4) : 635-648 (2007). Link
We are studying the signalling pathways involved in the maintenance and differentiation of the intestinal epithelial stem cells. We also study the function of differentiated cells in regulating the organism interactions with its environment, including the gut microbiota. Our experimental approach relies on a combination of mouse genetics, molecular and cellular biology and analyses at the pan-genomic scale. See more about the projects