SIGNALING, PLASTICITY AND CANCER
Department: Physiology and Cancer
Research subject
We develop and use cutting edge technologic tools such as “ribosome profiling” and “methylated RNA immunoprecipitation sequencing”(MeRIP-seq). We have established a library of patient derived cell lines from primary tumor, liver metastasis and blood. The team has now acquired a real expertise in the use of mouse models (xenografts and transgenic mice) and patient biopsies thanks to close collaborations with local hospitals (Nîmes and Montpellier). Translational research is always a priority in our research and this is highlighted not only by the development of innovative therapies and clinical tools but also by the presence of Dr Samalin (Digestive Oncologist, ICM) recently welcomed in the team. Finally, our team is highly involved in the SUNRiSE network, which federate several French teams focusing on cancer stem cells in solid tumors.
Team
Major publications
- Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture. Grillet F, Bayet E, Villeronce O, Zappia L, Lagerqvist EL, Lunke S, Charafe-Jauffret E, Pham K, Molck C, Rolland N, Bourgaux JF, Prudhomme M, Philippe C, Bravo S, Boyer JC, Canterel-Thouennon L, Taylor GR, Hsu A, Pascussi JM, Hollande F, Pannequin J. Gut. 2017 Oct;66(10):1802-1810.
- Pregnane X-receptor promotes stem cell-mediated colon cancer relapse. Planque C, Rajabi F, Grillet F, Finetti P, Bertucci F, Gironella M, Lozano JJ, Beucher B, Giraud J, Garambois V, Vincent C, Brown D, Caillo L, Kantar J, Pelegrin A, Prudhomme M, Ripoche J, Bourgaux JF, Ginestier C, Castells A, Hollande F, Pannequin J, Pascussi JM. Oncotarget. 2016 Aug 30;7(35):56558-56573.
- Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells. Giraud J, Failla LM, Pascussi JM, Lagerqvist EL, Ollier J, Finetti P, Bertucci F, Ya C, Gasmi I, Bourgaux JF, Prudhomme M, Mazard T, Ait-Arsa I, Houhou L, Birnbaum D, Pélegrin A, Vincent C, Ryall JG, Joubert D, Pannequin J, Hollande F. Cancer Res. 2016 Jun 15;76(12):3618-28.
- Antibiotics inhibit sphere-forming ability in suspension culture. Relier S, Yazdani L, Ayad O, Choquet A, Bourgaux JF, Prudhomme M, Pannequin J, Macari F, David A. Cancer Cell Int. 2016 Feb 12;16:6. doi: 10.1186/s12935-016-0277-6
- TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis. Macari F, El-Houfi Y, Boldina G, Xu H, Khoury-Hanna S, Ollier J, Yazdani L, Zheng G, Bièche I, Legrand N, Paulet D, Durrieu S, Byström A, Delbecq S, Lapeyre B, Bauchet L, Pannequin J, Hollande F, Pan T, Teichmann M, Vagner S, David A, Choquet A, Joubert D. Oncogene. 2016 Apr 7;35(14):1785-96.