MOLECULAR AND STRUCTURAL PHARMACOLOGY OF MEMBRANE PROTEINS
Department : Physiology and Cancer
Research subject
Transmembrane signaling is crucial to human physiology and disease but the molecular mechanisms of such an important process is poorly understood. Our research focuses on the molecular and structural bases of membrane protein signal transduction using molecular pharmacology and structural biology approaches. More particularly, we are studying key signaling proteins that possess an important potential for drug discovery programs such as seven transmembrane proteins (GPCRs and PAQRs).
Team
Team leader
Researchers
Technicians and engineers
Postdoctoral researchers and doctoral students
Fixed term contract technicians and engineers
Major publications
-
Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy. Nat. Comm. 2018, 9(1), 5437. Vasiliauskaité-Brooks I.; Healey R.D.; Rochaix P.; Saint-Paul J.; Sounier R.; Grison C.; Waltrich-Augusto T.; Fortier M.; Hoh F.; Saied E.M.; Arenz C.; Basu S.; Leyrat C.; Granier S.
-
Structural insights into adiponectin receptors suggest ceramidase activity.Nature 2017, 544 (7648), 120-3.Vasiliauskaité-Brooks, I.; Sounier, R.; Rochaix, P.; Bellot, G.; Fortier, M.; Hoh, F.; De Colibus, L.; Bechara, C.; Saied, E.M.; Arenz, C.; Leyrat, C.; Granier, S.
- Propagation of conformational changes during mu-opioid receptor activation. Nature 2015, 524 (7565), 375-8. Sounier, R.; Mas, C.; Steyaert, J.; Laeremans, T.; Manglik, A.; Huang, W.; Kobilka, B. K.; Demene, H.; Granier, S.
- Structural insights into micro-opioid receptor activation. Nature 2015, 524 (7565), 315-2. Huang, W.; Manglik, A.; Venkatakrishnan, A. J.; Laeremans, T.; Feinberg, E. N.; Sanborn, A. L.; Kato, H. E.; Livingston, K. E.; Thorsen, T. S.; Kling, R. C.; Granier, S.; Gmeiner, P.; Husbands, S. M.; Traynor, J. R.; Weis, W. I.; Steyaert, J.; Dror, R. O.; Kobilka, B. K.
- Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy. Proc. Natl. Acad. Sci. USA 2012, 109 (17), 6733-8. Rahmeh, R.; Damian, M.; Cottet, M.; Orcel, H.; Mendre, C.; Durroux, T.; Sharma, K. S.; Durand, G.; Pucci, B.; Trinquet, E.; Zwier, J. M.; Deupi, X.; Bron, P.; Baneres, J. L.; Mouillac, B.; Granier, S.
- Crystal structure of the micro-opioid receptor bound to a morphinan antagonist. Nature 2012, 485 (7398), 321-6. Manglik, A.; Kruse, A. C.; Kobilka, T. S.; Thian, F. S.; Mathiesen, J. M.; Sunahara, R. K.; Pardo, L.; Weis, W. I.; Kobilka, B. K.; Granier, S.
- Structure of the delta-opioid receptor bound to naltrindole. Nature 2012, 485 (7398), 400-4. Granier, S.; Manglik, A.; Kruse, A. C.; Kobilka, T. S.; Thian, F. S.; Weis, W. I.; Kobilka, B. K.