TSS

RHO GTPASE SIGNALLING IN NEURONAL DEVELOPMENT

Anne DEBANT
CRBM, Montpellier

Neuronal connectivity is based on complex developmental processes, such as axon outgrowth and guidance, dendritic arborisation, and synaptogenesis. Disruption of these processes can lead to neurological diseases, such as schizophrenia, autism spectrum disorders (ASD) and intellectual disability (ID). These developmental processes rely on the coordination of actin cytoskeleton remodelling and microtubule dynamics. Rho GTPases are major players in neuronal morphogenesis because they control actin cytoskeleton remodelling. Our long-term interest is to understand how Rho GTPase signalling controls axon outgrowth and guidance as well as synaptogenesis. My seminar will focus on the mechanisms by which Rho GTPase signalling contributes to the coordination between actin cytoskeleton remodelling and microtubule dynamics. I will also discuss how deregulation of Rho GTPase signalling could contribute to neurological diseases