Zsolt LENKEI

Séminaire externe
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Date: 2016-10-18 10:00

Lieu: Genopolys  |  Ville: Montpellier, France

CANNABINOID-INDUCED ACTOMYOSIN CONTRACTION SHAPES NEURONAL STRUCTURE AND CONNECTIVITY AT MULTIPLE SPATIOTEMPORAL SCALES

Zsolt LENKEI
(ESPCI Paris)

We have recently shown rapid cannabinoid-induced remodeling of the neuronal actomyosin cytoskeleton with potentially important roles in developmental brain wiring. Our recent results indicate a role for cannabinoid-induced actomyosin contraction also in synaptic plasticity. Completing our in vitro and ex vivo tools, we participate in the interdisciplinary development of a new in vivo imaging modality, functional fast brain ultrasound (fUS), to investigate the role of cannabinoid-induced actomyosin contraction in the structure and connectivity of the living rodent brain. fUS offers fMRI-like functional imaging, both in anaesthetised and awake animals, with spatio-temporal resolution gains of several orders of magnitude as compared to fMRI.

 

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34090 Montpellier, France

 

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