Les publications MAJEURES à l'IGF / IGF MAJOR publications

2017

  • Bouschet T, Dubois E, Reynes C, Kota SK, Rialle S, Maupetit-Mehouas S, Pezet M, Le Digarcher A, Nidelet S, Demolombe V, Cavelier P, Meusnier C, Maurizy C, Sabatier R, Feil R, Arnaud P, Journot L, Varrault A (2017) In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression. Cereb Cortex 27:2418-2433.
  • Cassier E, Gallay N, Bourquard T, Claeysen S, Bockaert J, Crepieux P, Poupon A, Reiter E, Marin P, Vandermoere F (2017) Phosphorylation of beta-arrestin2 at Thr383 by MEK underlies beta-arrestin-dependent activation of Erk1/2 by GPCRs. Elife 6.
  • Ciolek J et al. (2017) Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease. Proc Natl Acad Sci U S A 114:7154-7159.
  • Malinova A, Cvackova Z, Mateju D, Horejsi Z, Abeza C, Vandermoere F, Bertrand E, Stanek D, Verheggen C (2017) Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones. J Cell Biol 216:1579-1596.
  • Moreno Delgado D, Moller TC, Ster J, Giraldo J, Maurel D, Rovira X, Scholler P, Zwier JM, Perroy J, Durroux T, Trinquet E, Prezeau L, Rondard P, Pin JP (2017) Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells. Elife 6.
  • Scholler P, Moreno-Delgado D, Lecat-Guillet N, Doumazane E, Monnier C, Charrier-Savournin F, Fabre L, Chouvet C, Soldevila S, Lamarque L, Donsimoni G, Roux T, Zwier JM, Trinquet E, Rondard P, Pin JP (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13:372-380.
  • Smith N, Pietrancosta N, Davidson S, Dutrieux J, Chauveau L, Cutolo P, Dy M, Scott-Algara D, Manoury B, Zirafi O, McCort-Tranchepain I, Durroux T, Bachelerie F, Schwartz O, Munch J, Wack A, Nisole S, Herbeuval JP (2017) Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat Commun 8:14253.
  • Vasiliauskaite-Brooks I, Sounier R, Rochaix P, Bellot G, Fortier M, Hoh F, De Colibus L, Bechara C, Saied EM, Arenz C, Leyrat C, Granier S (2017) Structural insights into adiponectin receptors suggest ceramidase activity. Nature 544:120-123.
  • Romanò N, Guillou A, Hodson DJ, Martin AO, Mollard P (2017) Multiple-scale neuroendocrine signals connect brain and pituitary hormone rhythms. Proc Natl Acad Sci U S A. 2017 Feb 28; 114(9):2379-238
  • Wissem Deraredj Nadim, Séverine Chaumont-Dubel, Fahima Madouri, Laetitia Cobret, Marie-Ludivine De Tauzia, Pawel Zajdel, Hélène Bénédetti, Philippe Marin & Séverine Morisset-Lopez (2017) Physical interaction between neurofibromin andserotonin 5-HT6 receptor promotes receptor constitutive activity. PNAS  2379–2382 
  •  Alexander Barre, Coralie Berthoux, Dimitri De Bundel, Emmanuel Valjent, Joël Bockaert, Philippe Marin, Carine Bécamel (2017) Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning. PNAS E1382–E1391

2016

  • Pin J-P, Bettler B (2016) Organization and functions of mGlu and GABAB receptor complexes. Nature 540:60-68.
  • Telley L, Cadilhac C, Cioni JM, Saywell V, Jahannault-Talignani C, Huettl RE, Sarrailh-Faivre C, Dayer A, Huber AB, Ango F (2016) Dual Function of NRP1 in Axon Guidance and Subcellular Target Recognition in Cerebellum. Neuron 91:1276-1291.
  • Deraredj Nadim W, Chaumont-Dubel S, Madouri F, Cobret L, De Tauzia ML, Zajdel P, Benedetti H, Marin P, Morisset-Lopez S (2016) Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity. Proc Natl Acad Sci U S A 113:12310-12315.
  • Pradhan AA, Perroy J, Walwyn WM, Smith ML, Vicente-Sanchez A, Segura L, Bana A, Kieffer BL, Evans CJ (2016) Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function. J Neurosci 36:3541-3551.
  • Sobecki M et al. (2016) The cell proliferation antigen Ki-67 organises heterochromatin. Elife 5:e13722.
  • Rusconi F, Ceriotti P, Miragoli M, Carullo P, Salvarani N, Rocchetti M, Di Pasquale E, Rossi S, Tessari M, Caprari S, Cazade M, Kunderfranco P, Chemin J, Bang ML, Polticelli F, Zaza A, Faggian G, Condorelli G, Catalucci D (2016) Peptidomimetic Targeting of Cavbeta2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function. Circulation 134:534-546.
  • Barre A, Berthoux C, De Bundel D, Valjent E, Bockaert J, Marin P, Becamel C (2016) Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning. Proc Natl Acad Sci U S A 113:E1382-1391.
  • Broad J, Maurel D, Kung VW, Hicks GA, Schemann M, Barnes MR, Kenakin TP, Granier S, Sanger GJ (2016) Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design. Sci Rep 6:30797.
  • Courbet A, Renard E, Molina F (2016) Bringing next-generation diagnostics to the clinic through synthetic biology. EMBO Mol Med 8:987-991.
  • De Bundel D, Zussy C, Espallergues J, Gerfen CR, Girault JA, Valjent E (2016) Dopamine D2 receptors gate generalization of conditioned threat responses through mTORC1 signaling in the extended amygdala. Mol Psychiatry.
  • Gerbe F, Sidot E, Smyth DJ, Ohmoto M, Matsumoto I, Dardalhon V, Cesses P, Garnier L, Pouzolles M, Brulin B, Bruschi M, Harcus Y, Zimmermann VS, Taylor N, Maizels RM, Jay P (2016) Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature 529:226-230.
  • Golan M, Martin AO, Mollard P, Levavi-Sivan B (2016) Anatomical and functional gonadotrope networks in the teleost pituitary. Sci Rep 6:23777.
  • Goyet E, Bouquier N, Ollendorff V, Perroy J (2016) Fast and high resolution single-cell BRET imaging. Sci Rep 6:28231.
  • Grillet F et al. (2016) Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture. Gut.
  • Ke Y, Meyer T, Shih WM, Bellot G (2016) Regulation at a distance of biomolecular interactions using a DNA origami nanoactuator. Nat Commun 7:10935.
  • Mesirca P, Bidaud I, Briec F, Evain S, Torrente AG, Le Quang K, Leoni AL, Baudot M, Marger L, Chung You Chong A, Nargeot J, Striessnig J, Wickman K, Charpentier F, Mangoni ME (2016) G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block. Proc Natl Acad Sci U S A 113:E932-941.
  • Millan MJ et al. (2016) Altering the course of schizophrenia: progress and perspectives. Nat Rev Drug Discov 15:485-515.
  • Osterstock G, Mitutsova V, Barre A, Granier M, Fontanaud P, Chazalon M, Carmignac D, Robinson IC, Low MJ, Plesnila N, Hodson DJ, Mollard P, Mery PF (2016) Somatostatin triggers rhythmic electrical firing in hypothalamic GHRH neurons. Sci Rep 6:24394.
  • Plutoni C, Bazellieres E, Le Borgne-Rochet M, Comunale F, Brugues A, Seveno M, Planchon D, Thuault S, Morin N, Bodin S, Trepat X, Gauthier-Rouviere C (2016) P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces. J Cell Biol 212:199-217.


2015

  • Zhang W, Xu C, Tu H, Wang Y, Sun Q, Hu P, Hu Y, Rondard P, Liu J (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Sci Rep 5:10468.
  • Zampieri A, Champagne J, Auzemery B, Fuentes I, Maurel B, Bienvenu F (2015) Hyper sensitive protein detection by Tandem-HTRF reveals Cyclin D1 dynamics in adult mouse. Sci Rep 5:15739.
  • Seillier M et al. (2015) Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med 7:802-818.
  • Reynders A, Mantilleri A, Malapert P, Rialle S, Nidelet S, Laffray S, Beurrier C, Bourinet E, Moqrich A (2015) Transcriptional Profiling of Cutaneous MRGPRD Free Nerve Endings and C-LTMRs. Cell Rep.
  • Guo W, Ceolin L, Collins KA, Perroy J, Huber KM (2015) Elevated CaMKIIalpha and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model. Cell Rep 13:2297-2311.
  • Francois A, Schuetter N, Laffray S, Sanguesa J, Pizzoccaro A, Dubel S, Mantilleri A, Nargeot J, Noel J, Wood JN, Moqrich A, Pongs O, Bourinet E (2015) The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function. Cell Rep.
  • Blesneac I, Chemin J, Bidaud I, Huc-Brandt S, Vandermoere F, Lory P (2015) Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties. 112:13705-13710.
  • Arango-Lievano M, Lambert WM, Bath KG, Garabedian MJ, Chao MV, Jeanneteau F (2015) Neurotrophic-priming of glucocorticoid receptor signaling is essential for neuronal plasticity to stress and antidepressant treatment. Proc Natl Acad Sci U S A 112:15737-15742.
  • Bockaert J, Marin P (2015) mTOR in Brain Physiology and Pathologies. Physiol Rev 95:1157-1187.
  • Compan V, Pierredon S, Vanderperre B, Krznar P, Marchiq I, Zamboni N, Pouyssegur J, Martinou JC (2015) Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect. Mol Cell 59:491-501.
  • Delfosse V, Dendele B, Huet T, Grimaldi M, Boulahtouf A, Gerbal-Chaloin S, Beucher B, Roecklin D, Muller C, Rahmani R, Cavailles V, Daujat-Chavanieu M, Vivat V, Pascussi JM, Balaguer P, Bourguet W (2015) Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds. Nat Commun 6:8089.
  • Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK (2015) Structural insights into micro-opioid receptor activation. Nature 524:315-321.
  • Sounier R, Bellot G, Chou JJ (2015) Mapping conformational heterogeneity of mitochondrial nucleotide transporter in uninhibited states. Angew Chem Int Ed Engl 54:2436-2441.
  • Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Demene H, Granier S (2015) Propagation of conformational changes during mu-opioid receptor activation. Nature 524:375-378.
  • Penzo MA, Robert V, Tucciarone J, De Bundel D, Wang M, Van Aelst L, Darvas M, Parada LF, Palmiter RD, He M, Huang ZJ, Li B (2015) The paraventricular thalamus controls a central amygdala fear circuit. Nature 519:455-459.
  • Damian M, Mary S, Maingot M, M'Kadmi C, Gagne D, Leyris JP, Denoyelle S, Gaibelet G, Gavara L, Garcia de Souza Costa M, Perahia D, Trinquet E, Mouillac B, Galandrin S, Gales C, Fehrentz JA, Floquet N, Martinez J, Marie J, Baneres JL (2015) Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex. Proc Natl Acad Sci U S A 112:1601-1606.
  • Courbet A, Endy D, Renard E, Molina F, Bonnet J (2015) Detection of pathological biomarkers in human clinical samples via amplifying genetic switches and logic gates. Sci Transl Med 7:289ra283.
  • Al Adhami H, Evano B, Le Digarcher A, Gueydan C, Dubois E, Parrinello H, Dantec C, Bouschet T, Varrault A, Journot L (2015) A systems-level approach to parental genomic imprinting: the imprinted gene network includes extracellular matrix genes and regulates cell cycle exit and differentiation. Genome Res 25:353-367.
  • Xue L, Rovira X, Scholler P, Zhao H, Liu J, Pin J, Rondard P (2015) Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer. Nat Chem Biol 11:134-140.


2014

  • Bourinet E, Altier C, Hildebrand ME, Trang T, Salter MW, Zamponi GW (2014) Calcium-permeable ion channels in pain signaling. Physiol Rev 94:81-140.
  • Gaillard S, Lo Re L, Mantilleri A, Hepp R, Urien L, Malapert P, Alonso S, Deage M, Kambrun C, Landry M, Low SA, Alloui A, Lambolez B, Scherrer G, Le Feuvre Y, Bourinet E, Moqrich A (2014) GINIP, a Galphai-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia. Neuron 84:123-136
  • Olofsson L, Felekyan S, Doumazane E, Scholler P, Fabre L, Zwier JM, Rondard P, Seidel CA, Pin JP, Margeat E (2014) Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy. Nat Commun 5:5206.
  • Pittolo S, Gomez-Santacana X, Eckelt K, Rovira X, Dalton J, Goudet C, Pin JP, Llobet A, Giraldo J, Llebaria A, Gorostiza P (2014) An allosteric modulator to control endogenous G protein-coupled receptors with light. Nat Chem Biol 10:813-815.
  • Ady V, Perroy J, Tricoire L, Piochon C, Dadak S, Chen X, Dusart I, Fagni L, Lambolez B, Levenes C (2014) Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors. EMBO Rep 15:103-109.
  • Bjordal M, Arquier N, Kniazeff J, Pin J-P, Léopold P (2014) Amino acids sensing in a brain dopaminergic circuitry controls feeding behavior in Drosophila. Cell 156:510-521.
  • Duhr F, Deleris P, Raynaud F, Seveno M, Morisset-Lopez S, Mannoury la Cour C, Millan MJ, Bockaert J, Marin P, Chaumont-Dubel S (2014) Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth. Nat Chem Biol 10:590-597.
  • Garcia-Caballero A, Gadotti VM, Stemkowski P, Weiss N, Souza IA, Hodgkinson V, Bladen C, Chen L, Hamid J, Pizzoccaro A, Deage M, Francois A, Bourinet E, Zamponi GW (2014) The Deubiquitinating Enzyme USP5 Modulates Neuropathic and Inflammatory Pain by Enhancing Cav3.2 Channel Activity. Neuron 83:1144-1158.
  • Kovatchev BP et al. (2014) Safety of outpatient closed-loop control: first randomized crossover trials of a wearable artificial pancreas. Diabetes Care 37:1789-1796.
  • Lecoutey C, Hedou D, Freret T, Giannoni P, Gaven F, Since M, Bouet V, Ballandonne C, Corvaisier S, Malzert Freon A, Mignani S, Cresteil T, Boulouard M, Claeysen S, Rochais C, Dallemagne P (2014) Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment. Proc Natl Acad Sci U S A 111:E3825-3830.
  • Marchi N, Granata T, Janigro D (2014) Inflammatory pathways of seizure disorders. Trends Neurosci 37:55-65.
  • Nigro G, Rossi R, Commere PH, Jay P, Sansonetti PJ (2014) The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration. Cell Host Microbe 15:792-798.
  • Pascoli V, Terrier J, Espallergues J, Valjent E, O'Connor EC, Luscher C (2014) Contrasting forms of cocaine-evoked plasticity control components of relapse. Nature 509:459-464.
  • Naudin C, Sirvent A, Leroy C, Larive R, Simon V, Pannequin J, Bourgaux JF, Pierre J, Robert B, Hollande F, Roche S (2014) SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2. Nat Commun 5:3159.
  • Lapierre M, Bonnet S, Bascoul-Mollevi C, Ait-Arsa I, Jalaguier S, Del Rio M, Plateroti M, Roepman P, Ychou M, Pannequin J, Hollande F, Parker M, Cavailles V (2014) RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. J Clin Invest 124:1899-1913.
  • Breuker C, Planque C, Rajabi F, Nault JC, Couchy G, Zucman-Rossi J, Evrard A, Kantar J, Chevet E, Bioulac-Sage P, Ramos J, Assenat E, Joubert D, Pannequin J, Hollande F, Pascussi JM (2014) Characterization of a novel PXR isoform with potential dominant-negative properties. J Hepatol 61:609-616.
  • Mesirca P, Alig J, Torrente AG, Müller JC, Marger L, Rollin A, Marquilly C, Vincent A, Dubel S, Bidaud I, Fernandez A, Seniuk A, Engeland B, Singh J, Miquerol L, Ehmke H, Eschenhagen T, Nargeot J, Wickman K, Isbrandt D, Mangoni ME (2014). Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation. Nat Commun. 5:4664

2013

  • Andoniadou CL, Matsushima D, Mousavy Gharavy SN, Signore M, Mackintosh AI, Schaeffer M, Gaston-Massuet C, Mollard P, Jacques TS, Le Tissier P, Dattani MT, Pevny LH, Martinez-Barbera JP (2013) Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential. Cell Stem Cell 13:433-445.
  • Bonne-Andrea C, Kahli M, Mechali F, Lemaitre JM, Bossis G, Coux O (2013) SUMO2/3 modification of cyclin E contributes to the control of replication origin firing. Nat Commun 4:1850.
  • Cioni JM, Telley L, Saywell V, Cadilhac C, Jourdan C, Huber AB, Huang JZ, Jahannault-Talignani C, Ango F (2013) SEMA3A signaling controls layer-specific interneuron branching in the cerebellum. Curr Biol 23:850-861.
  • Doumazane E, Scholler P, Fabre L, Zwier JM, Trinquet E, Pin JP, Rondard P (2013) Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors. Proc Natl Acad Sci U S A 110:E1416-1425.
  • Kovatchev BP, Renard E, Cobelli C, Zisser HC, Keith-Hynes P, Anderson SM, Brown SA, Chernavvsky DR, Breton MD, Farret A, Pelletier MJ, Place J, Bruttomesso D, Del Favero S, Visentin R, Filippi A, Scotton R, Avogaro A, Doyle FJ, 3rd (2013) Feasibility of outpatient fully integrated closed-loop control: first studies of wearable artificial pancreas. Diabetes Care 36:1851-1858.
  • Liston C, Cichon JM, Jeanneteau F, Jia Z, Chao MV, Gan WB (2013) Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance. Nat Neurosci 16:698-705.
  • Pin JP (2013) Tuning synaptic activity with light-controlled GPCRs. Nat Neurosci 16:377-379.
  • Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE (2013) Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation 128:101-114.
  • Sah R, Mesirca P, Van den Boogert M, Rosen J, Mably J, Mangoni ME, Clapham DE (2013) Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proc Natl Acad Sci U S A 110:E3037-3046.
  • Sander V, Sune G, Jopling C, Morera C, Izpisua Belmonte JC (2013) Isolation and in vitro culture of primary cardiomyocytes from adult zebrafish hearts. Nat Protoc 8:800-809.
  • Schaeffer M, Langlet F, Lafont C, Molino F, Hodson DJ, Roux T, Lamarque L, Verdie P, Bourrier E, Dehouck B, Baneres JL, Martinez J, Mery PF, Marie J, Trinquet E, Fehrentz JA, Prevot V, Mollard P (2013) Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons. Proc Natl Acad Sci U S A 110:1512-1517.
  • Venables JP, Lapasset L, Gadea G, Fort P, Klinck R, Irimia M, Vignal E, Thibault P, Prinos P, Chabot B, Abou Elela S, Roux P, Lemaitre JM, Tazi J (2013) MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation. Nat Commun 4:2480.
  • Venkatakrishnan AJ, Deupi X, Lebon G, Tate CG, Schertler GF, Babu MM (2013) Molecular signatures of G-protein-coupled receptors. Nature 494:185-194.
  • Desarménien MG, Jourdan C, Toutain B, Vessières E, Hormuzdi SG, Guérineau NC (2013) Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo. Nat Commun. 4:2938.



2012

  • V1b and CRHR1 receptor heterodimerization mediates synergistic biological actions of vasopressin and CRH. Murat B, Devost D, Andrés M, Mion J, Boulay V, Corbani M, Zingg HH, Guillon G. Mol Endocrinol. 2012 Mar;26(3):502-20.
  • Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics. Manning M, Misicka A, Olma A, Bankowski K, Stoev S, Chini B, Durroux T, Mouillac B, Corbani M, Guillon G. J Neuroendocrinol. 2012 Apr;24(4):609-28. Review.
  • Engagement of β-arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation. Oligny-Longpré G, Corbani M, Zhou J, Hogue M, Guillon G, Bouvier M.
    Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):E1028-37.
  • Vasopressin inhibits LTP in the CA2 mouse hippocampal area. Chafai M, Corbani M, Guillon G, Desarménien MG. PLoS One. 2012;7(12):e49708.
  • Besnard E, Babled A, Lapasset L, Milhavet O, Parrinello H, Dantec C, Marin JM, Lemaitre JM (2012) Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs. Nat Struct Mol Biol 19:837-844.
  • Bonnans C, Flaceliere M, Grillet F, Dantec C, Desvignes JP, Pannequin J, Severac D, Dubois E, Bibeau F, Escriou V, Crespy P, Journot L, Hollande F, Joubert D (2012) Essential requirement for beta-arrestin2 in mouse intestinal tumors with elevated Wnt signaling. Proc Natl Acad Sci U S A 109:3047-3052.
  • Cobelli C, Renard E, Kovatchev BP, Keith-Hynes P, Ben Brahim N, Place J, Del Favero S, Breton M, Farret A, Bruttomesso D, Dassau E, Zisser H, Doyle FJ, 3rd, Patek SD, Avogaro A (2012) Pilot studies of wearable outpatient artificial pancreas in type 1 diabetes. Diabetes Care 35:e65-67.
  • El Moustaine D, Granier S, Doumazane E, Scholler P, Rahmeh R, Bron P, Mouillac B, Baneres JL, Rondard P, Pin JP (2012) Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling. Proc Natl Acad Sci U S A 109:16342-16347.
  • Geng Y, Xiong D, Mosyak L, Malito DL, Kniazeff J, Chen Y, Burmakina S, Quick M, Bush M, Javitch JA, Pin J-P, Fan QR (2012) Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2. Nat Neurosci 15:970-978.
  • Granier S, Kobilka B (2012) A new era of GPCR structural and chemical biology. Nat Chem Biol 8:670-673.
  • Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK (2012) Structure of the delta-opioid receptor bound to naltrindole. Nature 485:400-404.
  • Hlavackova V, Zabel U, Frankova D, Batz J, Hoffmann C, Prezeau L, Pin* JP, Blahos* J, Lohse* MJ (2012) Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1. Sci Signal 5:ra59.
  • Hodson DJ, Schaeffer M, Romano N, Fontanaud P, Lafont C, Birkenstock J, Molino F, Christian H, Lockey J, Carmignac D, Fernandez-Fuente M, Le Tissier P, Mollard P (2012) Existence of long-lasting experience-dependent plasticity in endocrine cell networks. Nat Commun 3:605.
  • Jeanneteau F, Lambert WM, Ismaili N, Bath KG, Lee FS, Garabedian MJ, Chao MV (2012) BDNF and glucocorticoids control corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. PNAS 109:1305-1310.
  • Jopling C, Sune G, Faucherre A, Fabregat C, Izpisua Belmonte JC (2012) Hypoxia induces myocardial regeneration in zebrafish. Circulation 126:3017-3027.
  • Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S (2012) Crystal structure of the micro-opioid receptor bound to a morphinan antagonist. Nature 485:321-326.
  • Meffre J, Chaumont-Dubel S, Mannoury la Cour C, Loiseau F, Watson DJ, Dekeyne A, Seveno M, Rivet JM, Gaven F, Deleris P, Herve D, Fone KC, Bockaert J, Millan MJ, Marin P (2012) 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia. EMBO Mol Med 4:1043-1056.
  • Moutin E, Raynaud F, Roger J, Pellegrino E, Homburger V, Bertaso F, Ollendorff V, Bockaert J, Fagni L, Perroy J (2012) Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability. J Cell Biol 198:251-263.
  • Neco P, Torrente AG, Mesirca P, Zorio E, Liu N, Priori SG, Napolitano C, Richard S, Benitah JP, Mangoni ME, Gomez AM (2012) Paradoxical effect of increased diastolic Ca2+ release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia. Circulation 126:392-401.
  • Oligny-Longpre G, Corbani M, Zhou J, Hogue M, Guillon G, Bouvier M (2012) Engagement of beta-arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation. Proc Natl Acad Sci U S A 109:E1028-1037.
  • Rahmeh R, Damian M, Cottet M, Orcel H, Mendre C, Durroux T, Sharma KS, Durand G, Pucci B, Trinquet E, Zwier JM, Deupi X, Bron P, Baneres JL, Mouillac B, Granier S (2012) Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy. Proc Natl Acad Sci U S A 109:6733-6738.
  • Riveline JP, Schaepelynck P, Chaillous L, Renard E, Sola-Gazagnes A, Penfornis A, Tubiana-Rufi N, Sulmont V, Catargi B, Lukas C, Radermecker RP, Thivolet C, Moreau F, Benhamou PY, Guerci B, Leguerrier AM, Millot L, Sachon C, Charpentier G, Hanaire H (2012) Assessment of patient-led or physician-driven continuous glucose monitoring in patients with poorly controlled type 1 diabetes using basal-bolus insulin regimens: a 1-year multicenter study. Diabetes Care 35:965-971.
  • Schumacher MA, Donnelly JM, Engevik AC, Xiao C, Yang L, Kenny S, Varro A, Hollande F, Samuelson LC, Zavros Y (2012) Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori. Gastroenterology 142:1150-1159 e1156.

2011

  • Phylogenetic diversity and functional efficacy of the C-terminally expressed heptapeptide unit in the opioid precursor polypeptide proenkephalin A. Bojnik E, Boynik E, Corbani M, Babos F, Magyar A, Borsodi A, Benyhe S. Neuroscience. 2011 Mar 31;178:56-67.
  • Design, synthesis, and pharmacological characterization of fluorescent peptides for imaging human V1b vasopressin or oxytocin receptors. Corbani M, Trueba M, Stoev S, Murat B, Mion J, Boulay V, Guillon G, Manning M. J Med Chem. 2011 Apr 28;54(8):2864-77.
  • Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nurnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, Engel J, Mangoni ME, Farooq M, Khan HU, Nurnberg P, Striessnig J, Bolz HJ (2011) Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness. Nat Neurosci 14:77-84.
  • Budry L, Lafont C, El Yandouzi T, Chauvet N, Conejero G, Drouin J, Mollard P (2011) Related pituitary cell lineages develop into interdigitated 3D cell networks. Proc Natl Acad Sci U S A 108:12515-12520.
  • Comps-Agrar L, Kniazeff J, Norskov-Lauritsen L, Maurel D, Gassmann M, Gregor N, Prezeau L, Bettler B, Durroux T, Trinquet E, Pin J-P (2011) The oligomeric state sets GABA(B) receptor signalling efficacy. EMBO J 30:2336-2349.
  • Descoeur J, Pereira V, Pizzoccaro A, Francois A, Ling B, Maffre V, Couette B, Busserolles J, Courteix C, Noel J, Lazdunski M, Eschalier A, Authier N, Bourinet E (2011) Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol Med 3:1-13.
  • Escobar M, Nicolas P, Sangar F, Laurent-Chabalier S, Clair P, Joubert D, Jay P, Legraverend C (2011) Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation. Nat Commun 2:258.
  • Gerbe F, van Es JH, Makrini L, Brulin B, Mellitzer G, Robine S, Romagnolo B, Shroyer NF, Bourgaux JF, Pignodel C, Clevers H, Jay P (2011) Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol 192:767-780.
  • Huang S, Cao J, Jiang M, Labesse G, Liu J, Pin* J-P, Rondard P (2011) Interdomain movements in metabotropic glutamate receptor activation. Proc Natl Acad Sci (USA) 108:15480-15485.
  • Jirawatnotai S, Hu Y, Michowski W, Elias JE, Becks L, Bienvenu F, Zagozdzon A, Goswami T, Wang YE, Clark AB, Kunkel TA, van Harn T, Xia B, Correll M, Quackenbush J, Livingston DM, Gygi SP, Sicinski P (2011) A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 474:230-234.
  • Jitsuki S, Takemoto K, Kawasaki T, Tada H, Takahashi A, Becamel C, Sano A, Yuzaki M, Zukin RS, Ziff EB, Kessels HW, Takahashi T (2011) Serotonin mediates cross-modal reorganization of cortical circuits. Neuron 69:780-792.
  • Jopling C, Boue S, Izpisua Belmonte JC (2011) Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat Rev Mol Cell Biol 12:79-89.
  • Lapasset L, Milhavet O, Prieur A, Besnard E, Babled A, Ait-Hamou N, Leschik J, Pellestor F, Ramirez JM, De Vos J, Lehmann S, Lemaitre JM (2011) Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. Genes Dev 25:2248-2253.
  • Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG (2011) Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation. Nature 474:521-525
  • Marger F, Gelot A, Alloui A, Matricon J, Ferrer JF, Barrere C, Pizzoccaro A, Muller E, Nargeot J, Snutch TP, Eschalier A, Bourinet E, Ardid D (2011) T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome. Proc Natl Acad Sci U S A 108:11268-11273.
  • Monnier C, Tu H, Bourrier E, Vol C, Lamarque L, Trinquet E, Pin J-P, Rondard P (2011) Transactivation between 7TM domains: implication in heterodimeric GABAB receptor activation EMBO J 30:32-42.
  • Odajima J, Wills ZP, Ndassa YM, Terunuma M, Kretschmannova K, Deeb TZ, Geng Y, Gawrzak S, Quadros IM, Newman J, Das M, Jecrois ME, Yu Q, Li N, Bienvenu F, Moss SJ, Greenberg ME, Marto JA, Sicinski P (2011) Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell 21:655-668.
  • Prieur A, Besnard E, Babled A, Lemaitre JM (2011) p53 and p16(INK4A) independent induction of senescence by chromatin-dependent alteration of S-phase progression. Nat Commun 2:473.
  • Ramirez JM, Gerbal-Chaloin S, Milhavet O, Qiang B, Becker F, Assou S, Lemaitre JM, Hamamah S, De Vos J (2011) Brief report: benchmarking human pluripotent stem cell markers during differentiation into the three germ layers unveils a striking heterogeneity: all markers are not equal. Stem Cells 29:1469-1474.
  • Roubille F, Franck-Miclo A, Covinhes A, Lafont C, Cransac F, Combes S, Vincent A, Fontanaud P, Sportouch-Dukhan C, Redt-Clouet C, Nargeot J, Piot C, Barrere-Lemaire S (2011) Delayed postconditioning in the mouse heart in vivo. Circulation 124:1330-1336.



2010

  • Agonist-selective dynamic compartmentalization of human Mu opioid receptor as revealed by resolutive FRAP analysis. Saulière-Nzeh Ndong A, Millot C, Corbani M, Mazères S, Lopez A, Salomé L. J Biol Chem. 2010 May 7;285(19):14514-20.
  • Albizu L, Cottet M, Kralikova M, Stoev S, Seyer R, Brabet I, Roux T, Bazin H, Bourrier E, Lamarque L, Breton C, Rives ML, Newman A, Javitch J, Trinquet E, Manning M, Pin JP, Mouillac B, Durroux T (2010) Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. Nat Chem Biol 6:587-594.
  • Bateup HS, Santini E, Shen W, Birnbaum S, Valjent E, Surmeier DJ, Fisone G, Nestler EJ, Greengard P (2010) Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors. Proc Natl Acad Sci U S A 107:14845-14850.
  • Bockaert J, Perroy J, Becamel C, Marin P, Fagni L (2010) GPCR interacting proteins (GIPs) in the nervous system: Roles in physiology and pathologies. Annu Rev Pharmacol Toxicol 50:89-109.
  • Buchert M, Papin M, Bonnans C, Darido C, Raye WS, Garambois V, Pelegrin A, Bourgaux JF, Pannequin J, Joubert D, Hollande F (2010) Symplekin promotes tumorigenicity by up-regulating claudin-2 expression. Proc Natl Acad Sci U S A 107:2628-2633.
  • Godin JD, Poizat G, Hickey MA, Maschat F, Humbert S (2010) Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease. EMBO J 29:2433-2445.
  • Lafont C, Desarmenien MG, Cassou M, Molino F, Lecoq J, Hodson D, Lacampagne A, Mennessier G, El Yandouzi T, Carmignac D, Fontanaud P, Christian H, Coutry N, Fernandez-Fuente M, Charpak S, Le Tissier P, Robinson IC, Mollard P (2010) Cellular in vivo imaging reveals coordinated regulation of pituitary microcirculation and GH cell network function. Proc Natl Acad Sci U S A 107:4465-4470.
  • Legraverend C, Escobar M, Jay P (2010) "The immortal DNA strand": difficult to digest? Cell Stem Cell 6:298-299; author reply 299.
  • Magalhaes A, Holmes K, Dale LB, Drysdale L, Comps-Agrar L, Lee D, Poulter MO, Pin J-P, Anisman H, Ferguson SSG (2010) CRF receptor1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nat Neurosci 13:622-629.
  • Raynal C, Pascussi JM, Leguelinel G, Breuker C, Kantar J, Lallemant B, Poujol S, Bonnans C, Joubert D, Hollande F, Lumbroso S, Brouillet JP, Evrard A (2010) Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation. Mol Cancer 9:46.
  • Renard E, Place J, Cantwell M, Chevassus H, Palerm CC (2010) Closed-loop insulin delivery using a subcutaneous glucose sensor and intraperitoneal insulin delivery: feasibility study testing a new model for the artificial pancreas. Diabetes Care 33:121-127.
  • Sanchez-Cardenas C, Fontanaud P, He Z, Lafont C, Meunier AC, Schaeffer M, Carmignac D, Molino F, Coutry N, Bonnefont X, Gouty-Colomer LA, Gavois E, Hodson DJ, Le Tissier P, Robinson IC, Mollard P (2010) Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood. Proc Natl Acad Sci U S A 107:21878-21883.
  • Ulmann L, Hirbec H, Rassendren F (2010) P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain. EMBO J 29:2290-2300.
  • Wong WP, Tiano JP, Liu S, Hewitt SC, Le May C, Dalle S, Katzenellenbogen JA, Katzenellenbogen BS, Korach KS, Mauvais-Jarvis F (2010) Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis. Proc Natl Acad Sci U S A 107:13057-13062.
  • Xiao C, Ogle SA, Schumacher MA, Orr-Asman MA, Miller ML, Lertkowit N, Varro A, Hollande F, Zavros Y (2010) Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology 138:550-561, 561 e551-558.



2009

  • Selective and high affinity labeling of neuronal and recombinant nociceptin receptors with the hexapeptide radioprobe [(3)H]Ac-RYYRIK-ol. Bojnik E, Farkas J, Magyar A, Tömböly C, Güçlü U, Gündüz O, Borsodi A, Corbani M, Benyhe S. Neurochem Int. 2009 Dec;55(7):458-66.
  • Alig J, Marger L, Mesirca P, Ehmke H, Mangoni ME, Isbrandt D (2009) Control of heart rate by cAMP sensitivity of HCN channels. Proc Natl Acad Sci U S A 106:12189-12194.
  • Annicotte JS, Blanchet E, Chavey C, Iankova I, Costes S, Assou S, Teyssier J, Dalle S, Sardet C, Fajas L (2009) The CDK4-pRB-E2F1 pathway controls insulin secretion. Nat Cell Biol 11:1017-1023.
  • Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier LP, Augier J, Kang DS, Claeysen S, Reiter E, Baneres JL, Benovic JL, Marin P, Bockaert J, Dumuis A (2009) Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. EMBO J 28:2706-2718.
  • Bianchi G, Oliva L, Cascio P, Pengo N, Fontana F, Cerruti F, Orsi A, Pasqualetto E, Mezghrani A, Calbi V, Palladini G, Giuliani N, Anderson KC, Sitia R, Cenci S (2009) The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition. Blood 113:3040-3049.
  • Buchert M, Darido C, Lagerqvist E, Sedello A, Cazevieille C, Buchholz F, Bourgaux JF, Pannequin J, Joubert D, Hollande F (2009) The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1. Gastroenterology 137:156-164, 164 e151-153.
  • Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers DM, Brown JH, Condorelli G (2009) Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol 184:923-933.
  • Dworkin S, Malaterre J, Hollande F, Darcy PK, Ramsay RG, Mantamadiotis T (2009) cAMP response element binding protein is required for mouse neural progenitor cell survival and expansion. Stem Cells 27:1347-1357.
  • Ferre S, Baler R, Bouvier M, Caron MG, Devi LA, Durroux T, Fuxe K, George SR, Javitch JA, Lohse MJ, Mackie K, Milligan G, Pfleger KDG, Pin J-P, Volkow N, Waldhoer M, Woods AS, Franco R (2009) Building a New Conceptual Framework for Receptor Heteromers. Nat Chem Biol 5:131-134.
  • Gerbe F, Brulin B, Makrini L, Legraverend C, Jay P (2009) DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium. Gastroenterology 137:2179-2180; author reply 2180-2171.
  • Lemaire K, Ravier MA, Schraenen A, Creemers JW, Van de Plas R, Granvik M, Van Lommel L, Waelkens E, Chimienti F, Rutter GA, Gilon P, in't Veld PA, Schuit FC (2009) Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci U S A 106:14872-14877.
  • Mitri C, Soustelle L, Framey B, Bockaert J, Parmentier M-L, Grau Y (2009) Plant Insecticide L-canavanine Repels Drosophila, via the Insect Orphan GPCR DmX. PLoS Biology 7:e1000147.
  • Raccah D, Sulmont V, Reznik Y, Guerci B, Renard E, Hanaire H, Jeandidier N, Nicolino M (2009) Incremental value of continuous glucose monitoring when starting pump therapy in patients with poorly controlled type 1 diabetes: the RealTrend study. Diabetes Care 32:2245-2250.
  • Rives ML, Vol C, Fukazawa Y, Tinel N, Trinquet E, Ayoub MA, Shigemoto R, Pin JP, Prezeau L (2009) Crosstalk between GABA(B) and mGlu1a receptors reveals new insight into GPCR signal integration. EMBO J 28:2195-2208.
  • Santini E, Heiman M, Greengard P, Valjent E, Fisone G (2009) Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia. Sci Signal 2:ra36.
  • Swayne LA, Mezghrani A, Varrault A, Chemin J, Bertrand G, Dalle S, Bourinet E, Lory P, Miller RJ, Nargeot J, Monteil A (2009) The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line. EMBO Rep 10:873-880.

2008

  • Ango F, Wu C, Van der Want JJ, Wu P, Schachner M, Huang ZJ (2008) Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. PLoS Biol 6:e103.
  • Bertaso F, Zhang C, Scheschonka A, de Bock F, Fontanaud P, Marin P, Huganir RL, Betz H, Bockaert J, Fagni L, Lerner-Natoli M (2008) PICK1 uncoupling from mGluR7a causes absence-like seizures. Nat Neurosci 11:940-948.
  • Chaumont S, Compan V, Toulme E, Richler E, Housley GD, Rassendren F, Khakh BS (2008) Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1. Sci Signal 1:ra8.
  • Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL (2008) Engineering GPCR signaling pathways with RASSLs. Nat Methods 5:673-678.
  • Cuvier O, Stanojcic S, Lemaitre JM, Mechali M (2008) A topoisomerase II-dependent mechanism for resetting replicons at the S-M-phase transition. Genes Dev 22:860-865.
  • Krasinska L, Besnard E, Cot E, Dohet C, Mechali M, Lemaitre JM, Fisher D (2008) Cdk1 and Cdk2 activity levels determine the efficiency of replication origin firing in Xenopus. EMBO J 27:758-769.
  • Mangoni ME, Nargeot J (2008) Genesis and regulation of the heart automaticity. Physiol Rev 88:919-982.
  • Maurel D, Comps-Agrar L, Brock C, Rives M-L, Bourrier E, Ayoub MA, Bazin H, Tinel N, Durroux T, Prézeau L, Trinquet E, Pin J-P (2008) Cell surface protein-protein interaction analysis with combined time-resolved FRET and snap-tag technologies: application to GPCR oligomerization. Nat Methods 5:561-567.
  • Pickup JC, Renard E (2008) Long-acting insulin analogs versus insulin pump therapy for the treatment of type 1 and type 2 diabetes. Diabetes Care 31 Suppl 2:S140-145.
  • Rondard P, Huang S, Monnier C, Tu H, Blanchard B, Oueslati N, Malhaire F, Li Y, Maurel D, Trinquet E, Labesse G, Pin* J-P, Liu J (2008) Functioning of the dimeric GABAB receptor extracellular domain revealed by glycan wedge scanning. EMBO J 27:1321-1332.




 

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