NEURORECEPTORS, DYNAMICS AND FUNCTION
Department: Neurosciences - Research axis: GPCR signaling

Research subject

Glutamate and gamma-amminobutyric acid (GABA) are the main excitatory and inhibitory neurotransmitters of the nervous system. They act on ligand-gated ion channels which are responsible for fast synaptic responses. They also modulate synaptic activity through the activation of G protein-coupled receptors (GPCR): metabotropic glutamate receptors (mGlu) and GABAB receptors. These receptors are considered as promising therapeutic targets for the treatment of various neurological and psychiatric disorders.

To identify new means and strategies to modulate their activity in vivo, our team is working at deciphering their mechanisms of activation at molecular and cellular levels, and at analyzing their association in signaling protein complexes. Thanks to the development of new technologies, we have revealed novel concepts about GPCR function, notably their association in dimers and higher order oligomers, and their asymmetrical mode of action. This knowledge allows us to identify new agents acting on mGlu and GABAB receptors and to highlight their therapeutic potential in Parkinson’s disease and pain.

Team Supported by the Fondation pour la Recherche Médicale (FRM DEQ20130326522)

 

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Team

Team leader

Jean-Philippe Pin
DRCE, CNRS


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Laurent Prezeau
DR2, CNRS


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Staff

Isabelle Brabet
IE, CNRS


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Samuel Bradley
Master 2, CNRS


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Léa Clusan
IE CDD, CNRS


  IGF Nord 221

  04 34 35 93 07

 

Paul Dembélé
Accueil scientifique, CNRS


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Joan Font-Ingles
Post-doctorant(e), CNRS


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Cyril Goudet
CRCN, CNRS


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Flavien Grégoire
IE CDD, CNRS


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Mélodie Guery
AI CDD, CNRS


  IGF Nord 209a

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Jordi Haubrich
Doctorant(e), Inserm


  IGF Nord 215

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Julie Kniazeff
CRCN, CNRS


  IGF Nord 221a

  04 34 35 92 96

 

Fanny Malhaire
IE CDI, CNRS


  IGF Nord 209a

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Michaël Mathieu
IE CDD, CNRS


  IGF Nord 215a

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JiYong Meng
Doctorant(e), CNRS


  IGF Nord 215a

  04 34 35 92 78

 

Mathieu Oosterlaken
Doctorant(e), UM


  IGF Nord 221a

  04 34 35 93 07

 

Vanessa Pereira
Post-doctorant(e), CNRS


  IGF Nord 209a

  04 34 35 92 77

 

Philippe Rondard
DR2, Inserm


  IGF Nord 215b

  04 34 35 92 78

 

Julien Soulé
IECN, CNRS


  IGF Nord 215a

  04 34 35 92 78

 

Claire Vol
IE, CNRS


  IGF-Nord 225

  04 34 35 93 13

 

Li Xue
Chercheur CDD, CNRS


  IGF Nord 216a

  04 34 35 92 78

 


Major publications

 

Events