PATHOPHYSIOLOGY OF SYNAPTIC TRANSMISION
Department: Neurosciences - Research axis: GPCR signaling

Research subject

The synapse is the structural entity allowing the communication between neurons in our brain. Understanding the functioning of the synapse will soon enable to discover new therapeutic strategies to treat neurologic and psychiatric disorders. This objective might be one of the more ambitious and exciting challenges in science for the XXI century! Our research investigations are designed to identify the best therapeutic targets. Concentring on the more frequent neuronal disorders -mental retardation, epilepsies and neurodegenerative diseases-, we are studying the molecular and cellular determinants involved in the control of the formation of synapses, the synaptic transmission and the synaptic plasticity. Our attention is particularly focused on the identification of synaptic proteins involved in subcellular trafficking, organization of the proteins at the synapse, and glutamate receptors signalling.

 

img.perroy.200

 

LINK TO TEAM WEB SITE


erc banner horizontal

 

Team

Team leader

Julie Perroy
DR2, CNRS


  IGF Sud 215 bis

  04 34 35 92 09

 

Staff

Federica Bertaso
CRCN, Inserm


  IGF Sud 227

  04 34 35 92 10

 

Nathalie Bouquier
IECN, CNRS


  IGF Sud 227

  04 34 35 92 10

 

Yan Chastagnier
IE CDD, CNRS


  IGF Sud 227

 

 

Laurent Fagni
DR1, CNRS


  IGF Sud 215b

  04 34 35 92 09

 

Benoit Girard
Doctorant(e), UM


  IGF Sud 227

  04 34 35 92 10

 

Paul Gratias
Master 2, CNRS


  IGF Sud 227

  04 34 35 92 10

 

Jennifer Jiner
AI CDD, CNRS


  IGF Sud 202

  04 34 35 92 12

 

Enora Moutin
Chercheur CDD, CNRS


  IGF Sud 227

  04 34 35 92 10

 

Julien Pico
Stagiaire, Inserm


  IGF Sud 227

  04 34 35 92 09

 

Sophie Sakkaki
Chercheur CDD, CNRS


  IGF Sud 227

  04 34 35 92 10

 

Jeanne Ster
CRCN, CNRS


  IGF Sud 225

  04 34 35 92 10

 

Vivien Szabo
Accueil scientifique, Inserm


  IGF Sud 227

  04 34 35 92 12

 


Major publications

  • Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network. Tassin, V., Girard B, Chotte A, Fontanaud P., Rigault D, Kalinichev M, Perroy J., Acher F., Fagni L, Bertaso F. (2016) Frontiers in Neural Circuits, 10: 31.
  • Fast and high resolution single-cell BRET imaging. Goyet E, Bouquier N, Ollendorf V, Perroy J. (2016) Scientific Reports, 6: 28231
  • Raynaud F, Janossy A, Dahl J, Bertaso F, Perroy J, Varrault A, Vidal M, Worley P, Boeckers TM, Bockaert J, Marin P, Fagni L and Homburger V. (2013) Shank3-Rich2 Interaction Regulates AMPA Receptor Recycling and Synaptic Long-term Potentiation J. Neurosc. Jun 5;33(23):9699-715
  • Moutin E, Raynaud F, Roger J, Pellegrino E, Homburger V, Bertaso F, Ollendorff V, Bockaert J, Fagni L, Perroy J. (2012) Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability. J Cell Biol. Jul 23;198(2):251-63
  • Moutin E, Raynaud F, Fagni L, Perroy J. (2012) GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity. J Cell Sci. Apr 15;125(Pt 8):2030-40.
 

Events