SIGNALING, PLASTICITY AND CANCER
Department: Cancer biology - Research axis: Translational biology

Research subject

Since cancer has been considered for ages as a disease of proliferation, identification of cancer stem cells has considerably changed this dogma. Cancer Stem Cells (CSC) represent a subpopulation of tumoral cells endowed with self-renewal, tumor initiation and resistance capacities. In the team we are focused on their signaling pathways and plasticity and we are studying more precisely their involvement in tumor recurrence in colorectal cancer. Our research is organized within 3 main axes. The first axis is focused on the deciphering of mechanisms explaining CSC chemoresistance in the aim of identifying innovative strategies to sensitize CSC to these drugs. The second axis proposes to study CSC plasticity through the angle of translational control, and especially by studying RNA modifications (epitranscriptome). Finally, tumoral dissemination is the topic of the third axis with a special focus on the circulating tumor cell characterization, early dissemination and tumor dormancy.

We develop and use cutting edge technologic tools such as “ribosome profiling” and “methylated RNA immunoprecipitation sequencing”(MeRIP-seq). We have established a library of patient derived cell lines from primary tumor, liver metastasis and blood. The team has now acquired a real expertise in the use of mouse models (xenografts and transgenic mice) and patient biopsies thanks to close collaborations with local hospitals (Nîmes and Montpellier). Translational research is always a priority in our research and this is highlighted not only by the development of innovative therapies and clinical tools but also by the presence of Dr Samalin (Digestive Oncologist, ICM) recently welcomed in the team. Finally, our team is highly involved in the SUNRiSE network, which federate several French teams focusing on cancer stem cells in solid tumors.

 

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Team

Team leader

Philippe Jay
DR2, Inserm


  IGF Nord 107a

  04 34 35 92 98

 

Staff

Lucile Bansard
AI CDD, CNRS


  IGF Nord 105b

  04 34 35 92 36

 

Amandine Bastide
Post-doctorant(e), Inserm


  IGF Nord 108b

  04 34 35 92 67

 

Guillaume Belthier
Doctorant(e), CNRS


  IGF Nord 108d

  04 34 35 93 21

 

Caroline Bonnans
CRCN, Inserm


  IGF Nord 108b

  04 34 35 92 67

 

Armelle Choquet
MCF, UM


  IGF Nord 107b

  04 34 35 92 67

 

Philippe Crespy
TCN, UM


  IGF Nord 108d

  04 34 35 93 21

 

Alexandre David
CRCN, Inserm


  IGF nord 106

  04 34 35 92 67

 

Bénédicte Dréan
AI CDD, CNRS


  IGF Nord 118

  04 34 35 93 21

 

Alessandro Giammona
Post-doctorant(e), UM


  IGF Nord 105b

  04 34 35 92 36

 

Hélène Guillorit
Doctorant(e), UM


  IGF Nord 108b

  04 34 35 92 65

 

Francoise Macari
MCF, UM


  IGF Nord 107b

  04 34 35 92 67

 

Élisa Moutin
Master 1, CNRS


  IGF Nord 108

  04 34 35 93 21

 

Julie Pannequin
CRCN, CNRS


  IGF Nord 108b

  04 34 35 92 65

 

Jean-Marc Pascussi
CRCN, Inserm


  IGF Nord 105b

  04 34 35 92 36

 

Chris Planque
MCF, UM


  IGF Nord 105b

  04 34 35 92 36

 

Sébastien Relier
Doctorant(e), UM


  IGF Nord 108

  04 34 35 92 67

 

Anaïs Riviere
Licence pro, UM


  IGF Nord 108b

  04 34 35 92 65

 

Olivia Villeronce
Doctorant(e), UM


  IGF Nord 106

  04 34 35 93 21

 

Jihane Vitre
IE CDD, CNRS


  IGF Nord 108d

  04 34 35 93 21

 


Major publications

  • Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture. Grillet F, Bayet E, Villeronce O, Zappia L, Lagerqvist EL, Lunke S, Charafe-Jauffret E, Pham K, Molck C, Rolland N, Bourgaux JF, Prudhomme M, Philippe C, Bravo S, Boyer JC, Canterel-Thouennon L, Taylor GR, Hsu A, Pascussi JM, Hollande F, Pannequin J. Gut. 2017 Oct;66(10):1802-1810

  • Pregnane X-receptor promotes stem cell-mediated colon cancer relapse. Planque C, Rajabi F, Grillet F, Finetti P, Bertucci F, Gironella M, Lozano JJ, Beucher B, Giraud J, Garambois V, Vincent C, Brown D, Caillo L, Kantar J, Pelegrin A, Prudhomme M, Ripoche J, Bourgaux JF, Ginestier C, Castells A, Hollande F, Pannequin J, Pascussi JM. Oncotarget. 2016 Aug 30;7(35):56558-56573.

  • Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells. Giraud J, Failla LM, Pascussi JM, Lagerqvist EL, Ollier J, Finetti P, Bertucci F, Ya C, Gasmi I, Bourgaux JF, Prudhomme M, Mazard T, Ait-Arsa I, Houhou L, Birnbaum D, Pélegrin A, Vincent C, Ryall JG, Joubert D, Pannequin J, Hollande F. Cancer Res. 2016 Jun 15;76(12):3618-28.

  • Antibiotics inhibit sphere-forming ability in suspension culture. Relier S, Yazdani L, Ayad O, Choquet A, Bourgaux JF, Prudhomme M, Pannequin J, Macari F, David A. Cancer Cell Int. 2016 Feb 12;16:6. doi: 10.1186/s12935-016-0277-6

  • TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis. Macari F, El-Houfi Y, Boldina G, Xu H, Khoury-Hanna S, Ollier J, Yazdani L, Zheng G, Bièche I, Legrand N, Paulet D, Durrieu S, Byström A, Delbecq S, Lapeyre B, Bauchet L, Pannequin J, Hollande F, Pan T, Teichmann M, Vagner S, David A, Choquet A, Joubert D.

 

 

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