NEURAL CIRCUITS FOR VALUE CODING AND VALUE-BASED DECISIONS
Department : Neuroscience - Research axis : Molecular & cellular networks

 

Research subject

To survive, animals constantly compare and make choices between several options based on the value assigned to each option during past experience. During associative learning, absolute (good or bad) and/or relative (better or worse than) values can be assigned to each experience.

The main goal of the lab is to decipher how, in the fly brain, value (absolute and relative) are assigned to sensory stimuli during learning and later used to make appropriate value-based/economic decisions. To tackle such evolutionary-conserved brain processes, the lab is using the fruit fly Drosophila melanogaster as a model combined with sophisticated genetics, in vivo two-photon calcium imaging, molecular biology and behavioural analysis.

 

img.e.perisse.web.jpg

 

Equipe ATIP-Avenir soutenue par La Fondation Bettencourt-Schueller

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Team

Team leader

Emmanuel Perisse
Chercheur Avenir, Inserm


  IGF Nord 003

  04 34 35 93 10

 

Staff

Major publications

  • Perisse E*, Owald D*, Barnstedt O, Talbot C, Huetteroth W and Waddell S. (2016) Aversive learning and appetitive motivation toggle feed-forward inhibition in the Drosophila mushroom body. Neuron, 90, 1-14.

  • Huetteroth W, Perisse E, Klappenbach M, Burke CJ, Lin S and Waddell S. (2015) Separated representations of sweet taste and nutrient value in rewarding dopaminergic neurons in Drosophila. Curr Biol, 25, 1-18.

  • Owald D, Felsenberg J, Das G, Perisse E, Talbot C, Huetteroth W, Waddell S. (2015) Activity of defined mushroom body output neurons underlies learned olfactory behavior in Drosophila. Neuron, 86, 1-11.

  • Perisse E, Yin Y, Lin A, Lin S, Huetteroth W, Waddell S. (2013) Different Kenyon cell populations drive learned approach and avoidance in Drosophila. Neuron, 79, 945–956.

  • Burke CJ, Huetteroth W, Owald D, Perisse E, Krashes MJ, Das G, Gohl D, Silies M, Certel S, Waddell S. (2012) Layered reward signalling through octopamine and dopamine in Drosophila. Nature, Dec 20;492(7429):433-7.

(*co-first author)

 

 

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