MOLECULAR AND STRUCTURAL BASES OF GPCR FUNCTION
Department: Physiology - Research axis: GPCR signaling

Research subject

Our work id focused on studying opioid receptors as well as arginine-vasopressin and oxytocin receptors, belonging to the G protein-coupled receptors (GPCR) superfamily. We investigate their structure and functioning, dynamics of their interactions with protein partners, and the links between these receptors and pathologies. This scientific program is dedicated to increase our knowledge in the field of transmembrane heptahelical receptors and their associated signaling pathways, and to develop new potential therapeutic molecules.

 

img.mouillac.200

Team

Team leader

Bernard Mouillac
DR2, Inserm


  IGF Nord 226b

  04 34 35 92 68

 

Staff

Julien Bous
Doctorant(e), UM


  IGF Nord 226

  04 34 35 92 68

 

Amélia Chorfa
Master 2, CNRS


  IGF Nord 224

  04 34 35 93 05

 

Maithé Corbani
CRCN, CNRS


  IGF Nord 020a

  04 34 35 92 94

 

Thierry Durroux
DR2, CNRS


  IGF Nord 204a

  04 34 35 92 64

 

Marc Fila
Collaborateur, CHU


  IGF Nord 224b

  04 34 35 93 05

 

Joyce Heuninck
Doctorant(e), CNRS


  IGF Nord 210a

  04 34 35 92 64

 

Christiane Mendre
CRCN, CNRS


  IGF Nord 224b

  04 34 35 93 05

 

Denis Morin
PU-PH, CHU


  CHU

  04 34 35 92 64

 

Helene Orcel
IECN, CNRS


  IGF Nord 226a

  04 34 35 93 02

 


Major publications

  • Rahmeh R, Damian M, Cottet M, Orcel H, Mendre C, Durroux T, Sharma KS, Durand G, Pucci B, Trinquet E, Zwier JM, Deupi X, Bron P, Banères JL, Mouillac B, Granier S. (2012). Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy. Proc Natl Acad Sci. 109(17), 6733-8.
  • Aashish Manglik, Andrew C. Kruse, Tong Sun Kobilka, Foon Sun Thian, Jesper M. Mathiesen, Roger K. Sunahara, Leonardo Pardo, William I. Weis, Brian K. Kobilka and Sébastien Granier (2012) Crystal structure of the mu-opioid receptor bound to a morphinan antagonist. Nature, 485(7398), 321-326.
  • Banères JL, Popot JL, Mouillac B. (2011) New advances in production and functional folding of G-protein-coupled receptors. Trends Biotechnol. 29(7), 314-22.
  • Albizu L, Cottet M, Kralikova M, Stoev S, Seyer R, Brabet I, Roux T, Bazin H, Bourrier E, Lamarque L, Breton C, Rives ML, Newman A, Javitch J, Trinquet E, Manning M, Pin JP, Mouillac B, Durroux T. (2010) Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. Nat. Chem. Biol. 6(8), 587-94.
  • Jean-Alphonse F, Perkovska S, Frantz M, Durroux T, Méjean C, Morin D, Loison S, Bonnet D, Hibert M, Mouillac B, Mendre C (2009) Biased agonists of the arginine-vasopressin V2 receptor : novel pharmacochaperones with therapeutic potential for treating congenital nephrogenic diabetes insipidus. J Am Soc Nephrol. 20(10) : 2190-2203.

 

 

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