Department: Neurosciences - Research axis: Molecular & cellular networks

Research subject

Selection and execution of appropriate behavioral responses rely on the ability to properly use sensory information to predict future rewards or punishments. The dorsal striatum, the nucleus accumbens and the extended amygdala are major structures critically involved in this learning process. The general objective of our research aims to characterize the molecular mechanisms resulting from the integration of dopamine and glutamate signals and to understand the functional impact of such events on dopamine-controlled learning and pathology.






Team leader

Emmanuel Valjent
CRCN, Inserm

  IGF Sud 219

  04 34 35 92 22



Laia Castell
Doctorant(e), UM

  IGF Sud 219

  04 34 35 92 22


Laura Cutando Ruiz
Post-doctorant(e), UM

  IGF Sud 220

  04 34 35 92 23


Pauline Tarot
Doctorant(e), Inserm

  IGF Sud 219

  04 34 35 92 22


Major publications

  • Biever A, Puighermanal E, Nishi A, David A, Panciatici C, Longueville S, Xirodimas X, Gangarossa G, Meyuhas O, Hervé D, Girault JA, Valjent E. PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spint neurons. J Neurosci. 2015 35(10):4113-30.
  • Puighermanal E, Biever A, Espallergues J, Gangarossa G, De Bundel D, Valjent E. Drd2-Cre:RiboTag mouse line unravels the possible diversity of dopamine D2 receptor-expressing cells of the dorsal mouse hippocampus. Hippocampus 2015 (ahead of print).
  • Pascoli V, Terrier J, Espallergues J, Valjent E, O'Connor EC, Lüscher C. Contrasting forms of cocaine-evoked plasticity control components of relapse. Nature 2014 509(7501):459-64.
  • Gangarossa G, Espallergues J, Mailly P, De Bundel D, de Kerchove d’Exaerde A, Hervé D, Girault JA, Valjent E, Krieger P. Spatial distribution of D1R- and D2R-expressing medium-sized spiny neurons differs along the rostro-caudal axis of the mouse dorsal striatum. Front Neural Circuits 2013 7:124.
  • Gangarossa G, Longueville S, De Bundel D, Perroy J, Hervé D, Girault JA, Valjent E. Characterization of dopamine D1 and D2 receptor-expressing neurons in the mouse hippocampus. Hippocampus 2012 22(12):2199-207.