ION CHANNELS IN NEURONAL EXCITABILITY AND DISEASES
Department: Neurosciences - Research axis: Biology of ion channels

Research subject

Our research activity is dedicated to the study of the properties of voltage-gated calcium channels (Cav) and sodium leak channels (NALCN). These ion channels are critically involved in the electrophysiological activity of excitable cells, especially neurons. Neurological diseases including epilepsy, migraine, ataxia, neuropathic pain, autism … can be linked to dysfunction of these channels and are called ‘channelopathies’.

Our current projects aim to characterize how these ion channels are involved in physiology and pathophysiology. We are particularly interested in deciphering the various aspects on the Cav and NALCN regulation. To do this we develop various complementary strategies, including mass spectrometry and patch-clamp techniques. A special effort is given to characterize how T-type calcium channels are modulated by endogenous ligands (lipids, zinc, phosphorylation …). We also investigate the pathogenic mechanisms underlying the calcium channelopathies (e.g. epilepsy and ataxia). In the long run, we would like to identify novel approaches to treat neurological diseases based on our knowledge of the basic properties of these channels and of the channelopathy mechanisms.

Our team is part of the Laboratory of Excellence "Ion Channel Science and Therapeutics" (LabEx ICST).

The team is awarded "Equipe FRM 2017"

 

 

img.lory.200

Team

Team leader

Philippe Lory
DR2, CNRS


  IGF Sud 129

  04 34 35 92 51

 

Staff

Jean Chemin
CRCN, CNRS


  IGF Sud 129

  04 34 35 92 50

 

Nathalie Guérineau
DR2, CNRS


  IGF Sud 129

  04 34 35 92 50

 

Hathaichanok Impheng
Doctorant(e), UM


  IGF Sud 129

  04 34 35 92 50

 

Alexandre Milman
Doctorant(e), CNRS


  IGF Sud 129

  04 34 35 92 50

 

Arnaud Monteil
CRCN, CNRS


  IGF Sud 129

  04 34 35 92 50

 

Zoé Servant
AI CDD, CNRS


  IGF Sud 103

  04 34 35 92 50

 


Major publications

  • Cazade M, Bidaud I, Lory P, Chemin J. (2017) Activity-dependent regulation of T-type calcium channels by submembrane calcium ions. Elife. Jan 21;6. pii: e22331.
  • Sakkaki S, Gangarossa G, Lerat B, Françon D, Forichon L, Chemin J, Valjent E, Lerner-Natoli M, Lory P (2016). Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model. Neuropharmacology. Feb;101:320-9
  • Blesneac I, Chemin J, Bidaud I, Huc-Brandt S, Vandermoere F, Lory P (2015). Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties. Proc Natl Acad Sci U S A. Nov 3;112(44):13705-10.
  • Coutelier M, Blesneac I, Monteil A, Monin ML, Ando K, Mundwiller E, Brusco A, Le Ber I, Anheim M, Castrioto A, Duyckaerts C, Brice A, Durr A, Lory P, Stevanin G (2015). A Recurrent Mutation in CACNA1G Alters Cav3.1 T-Type Calcium-Channel Conduction and Causes Autosomal-Dominant Cerebellar Ataxia. Am J Hum Genet. Nov 5;97(5):726-37.
  • Chong et al (2015). De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay. Am J Hum Genet. Mar 5;96(3):462-73.
  • Cazade M, Bidaud I, Hansen PB, Lory P, Chemin J (2014) 5,6-EET potently inhibits T-type calcium channels: implication in the regulation of the vascular tone. Pflugers Arch. Sep;466(9):1759-68

 

 

Events