WELCOME
The Institute of Functional Genomics (IGF) is a multidisciplinary research centre which is developing a project focused on the functional genomics of physiological and pathological cellular communications in the fields of neurobiology, endocrinology, oncology and cardiology.
This project is based on a multi-scale strategy from 'molecule to systems' and combines structural, biochemical, genetic, epigenetic, omics, physiological and behavioural studies. A major effort is paid to the development of single-cell studies through multiple dimensions and multi-omic approaches, that are necessary to address the complexity of life.
The project of IGF is increasingly based on translational research, promoted by the recruitment of teams of clinicians from different fields (neurovascular, diabetology, neuro-oncology and psychiatry). The objective is to identify new mechanisms and concepts in the field of cellular communications, in order to develop new therapeutic strategies and diagnostic tools.
Séminaire hybride
UNDERSTANDING HETEROGENEITY IN THE PANCREATIC ISLETS FROM THE SINGLE GPCR TO THE ORGANISM
DAVID HODSON
Institute of Metabolism and Systems Research - University of Birmingham
The past decade has seen explosive development in single cell screening and cell resolution imaging. These approaches have transformed our view of complex tissues such that cells deriving from the same progenitor pool, or expressing the same transcription factors, are now no longer considered to be entirely similar. The current presentation will describe recent work to understand and visualize functional heterogeneity in the pancreatic islets from the single GPCR to the organism (https://www.isletbiologylab.com/).
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