SEMINAIRE NEUROSCIENCES

INTERPLAY BETWEEN DOPAMINE AND PREFRONTAL CORTEX IN SELF-PACED DECISIONS

Jérémie NAUDET
Neuroscience Paris Seine, Sorbonne Université

Daily decisions are often self-generated, motivated by our goals rather than triggered by a stimulus. The neuromodulator dopamine is classically implicated in the learning of stimulus-triggered actions leading to rewards. Dopamine also affects self-paced decisions, probably through its interaction with frontal areas of the cortex. How self-paced decisions emerge from the dynamics of this meso-cortical circuit remains unclear. We addressed this question in a sequential decision task for mice allowing a combination of multi-site electrophysiological recordings, computational modeling and perturbation techniques. In this talk I will show two lines of results : how a distributed sequence of mesocortical activity may be causally linked to decisions, and how dopamine may exert an online regulation of frontal dynamics.

Attention, en raison des mesures sanitaires Covid-19, séminaire hybride en présentiel et distanciel
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