CHRISTOPHE DURANTON

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Category
Séminaire externe
Date
12 October 2018 11:00
Venue
IGF SUD Salle Pierre Soulages - 141 Rue de la Cardonille
34090 Montpellier, France
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CHLORIDE CHANNELS : permeable to Cl- ions but not only...

CHRISTOPHE DURANTON
CNRS-UMR 7370 - Laboratoire de Physio-médecine moléculaire Nice

Cl- ion channels have always been underestimated principally due to the difficulties to characterize their molecular identities and by the absence of specific inhibitors. A growing number of evidences suggest that chloride channels dynamically regulated intracellular chloride concentration and play a crucial role in the transmission of cellular signals by controlling oxidative stress level. In this seminar, I will summarize recent advances concerning 2 different chloride channels: CFTR and the VRAC/LRRC8. and their abilities to transport chloride ions but more surprisingly other substrates such as glutathione or ATP. I will also describe our latest findings identifying these 2 chloride channels as major actors in the control of cell destiny and the regulation of oxidative stress level.

 

 
 

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  • 12 October 2018 11:00

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