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The Institute of Functional Genomics (IGF) is a multidisciplinary research centre which is developing a project focused on the functional genomics of physiological and pathological cellular communications in the fields of neurobiology, endocrinology, oncology and cardiology.
This project is based on a multi-scale strategy from 'molecule to systems' and combines structural, biochemical, genetic, epigenetic, omics, physiological and behavioural studies. A major effort is paid to the development of single-cell studies through multiple dimensions and multi-omic approaches, that are necessary to address the complexity of life.
The project of IGF is increasingly based on translational research, promoted by the recruitment of teams of clinicians from different fields (neurovascular, diabetology, neuro-oncology and psychiatry). The objective is to identify new mechanisms and concepts in the field of cellular communications, in order to develop new therapeutic strategies and diagnostic tools.
CHLORIDE CHANNELS : permeable to Cl- ions but not only...
CHRISTOPHE DURANTON
CNRS-UMR 7370 - Laboratoire de Physio-médecine moléculaire Nice
Cl- ion channels have always been underestimated principally due to the difficulties to characterize their molecular identities and by the absence of specific inhibitors. A growing number of evidences suggest that chloride channels dynamically regulated intracellular chloride concentration and play a crucial role in the transmission of cellular signals by controlling oxidative stress level. In this seminar, I will summarize recent advances concerning 2 different chloride channels: CFTR and the VRAC/LRRC8. and their abilities to transport chloride ions but more surprisingly other substrates such as glutathione or ATP. I will also describe our latest findings identifying these 2 chloride channels as major actors in the control of cell destiny and the regulation of oxidative stress level.
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