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The Institute of Functional Genomics (IGF) is a multidisciplinary research centre which is developing a project focused on the functional genomics of physiological and pathological cellular communications in the fields of neurobiology, endocrinology, oncology and cardiology.
This project is based on a multi-scale strategy from 'molecule to systems' and combines structural, biochemical, genetic, epigenetic, omics, physiological and behavioural studies. A major effort is paid to the development of single-cell studies through multiple dimensions and multi-omic approaches, that are necessary to address the complexity of life.
The project of IGF is increasingly based on translational research, promoted by the recruitment of teams of clinicians from different fields (neurovascular, diabetology, neuro-oncology and psychiatry). The objective is to identify new mechanisms and concepts in the field of cellular communications, in order to develop new therapeutic strategies and diagnostic tools.
ULTRAFAST FUNCTIONAL ULTRASOUND IMAGING OF THE CENTRAL NERVOUS SYSTEM REVEALS DYSFUNCTIONS IN CHRONIC PAIN
Sophie Pezet & Michael Tanter
Laboratory of Brain Plasticity, CNRS UMR 8249, ESPCI, Paris, France
Le séminaire abordera une technologie prometteuse d'imagerie cérébrale par imagerie fonctionnelle à ultrasons (fUS) ultrarapide permettant un suivi longitudinal d'animaux et une résolution supérieure à l'IRM pour un coût matériel abordable. M Tanter développe cette imagerie ultrasonore qui est très prometteuse. Le but du séminaire est de présenter la technique et ses applications dans le contexte des travaux de Sophie Pezet sur le suivi longitudinal les réseaux neuronaux activés par la douleur chronique dans le cerveau et la moelle épinière de rongeurs. Pour en savoir plus: Errico et al (2015) Nature - Ultrafast ultrasound localization microscopy for deep super-resolution vascular Imaging. Tiran et al (2017) Ultrasound in Med and Biol - Transcranial functional ultrasound Imaging in freely moving awake mice and anesthetized Young rats without contrast agent.
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