WELCOME
The Institute of Functional Genomics (IGF) is a multidisciplinary research centre which is developing a project focused on the functional genomics of physiological and pathological cellular communications in the fields of neurobiology, endocrinology, oncology and cardiology.
This project is based on a multi-scale strategy from 'molecule to systems' and combines structural, biochemical, genetic, epigenetic, omics, physiological and behavioural studies. A major effort is paid to the development of single-cell studies through multiple dimensions and multi-omic approaches, that are necessary to address the complexity of life.
The project of IGF is increasingly based on translational research, promoted by the recruitment of teams of clinicians from different fields (neurovascular, diabetology, neuro-oncology and psychiatry). The objective is to identify new mechanisms and concepts in the field of cellular communications, in order to develop new therapeutic strategies and diagnostic tools.
OPTOGENETIC IN THE VISUAL SYSTEM : FROM CIRCUIT ANALYSIS TO VISUAL RESTORATION IN BLIND PATIENTS
Serge PICAUD
Institut de la vision, Paris
The eye is an open window on the central nervous system and more precisely on the retina providing thereby an ideal system for optogenetic applications in normal and pathological conditions. We are therefore taking advantage of optogenetic therapy to assess neuronal connections at single cell level and to restore vision in blind patients. In visual restoration, our preclinical data are paving the way for clinical trials due to start next year both on a new prosthetic device and on optogenetic therapy.
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