WELCOME
The Institute of Functional Genomics (IGF) is a multidisciplinary research centre which is developing a project focused on the functional genomics of physiological and pathological cellular communications in the fields of neurobiology, endocrinology, oncology and cardiology.
This project is based on a multi-scale strategy from 'molecule to systems' and combines structural, biochemical, genetic, epigenetic, omics, physiological and behavioural studies. A major effort is paid to the development of single-cell studies through multiple dimensions and multi-omic approaches, that are necessary to address the complexity of life.
The project of IGF is increasingly based on translational research, promoted by the recruitment of teams of clinicians from different fields (neurovascular, diabetology, neuro-oncology and psychiatry). The objective is to identify new mechanisms and concepts in the field of cellular communications, in order to develop new therapeutic strategies and diagnostic tools.
RHO GTPASE SIGNALLING IN NEURONAL DEVELOPMENT
Anne DEBANT
CRBM, Montpellier
Neuronal connectivity is based on complex developmental processes, such as axon outgrowth and guidance, dendritic arborisation, and synaptogenesis. Disruption of these processes can lead to neurological diseases, such as schizophrenia, autism spectrum disorders (ASD) and intellectual disability (ID). These developmental processes rely on the coordination of actin cytoskeleton remodelling and microtubule dynamics. Rho GTPases are major players in neuronal morphogenesis because they control actin cytoskeleton remodelling. Our long-term interest is to understand how Rho GTPase signalling controls axon outgrowth and guidance as well as synaptogenesis. My seminar will focus on the mechanisms by which Rho GTPase signalling contributes to the coordination between actin cytoskeleton remodelling and microtubule dynamics. I will also discuss how deregulation of Rho GTPase signalling could contribute to neurological diseases
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