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The Institute of Functional Genomics (IGF) is a multidisciplinary research centre which is developing a project focused on the functional genomics of physiological and pathological cellular communications in the fields of neurobiology, endocrinology, oncology and cardiology.
This project is based on a multi-scale strategy from 'molecule to systems' and combines structural, biochemical, genetic, epigenetic, omics, physiological and behavioural studies. A major effort is paid to the development of single-cell studies through multiple dimensions and multi-omic approaches, that are necessary to address the complexity of life.
The project of IGF is increasingly based on translational research, promoted by the recruitment of teams of clinicians from different fields (neurovascular, diabetology, neuro-oncology and psychiatry). The objective is to identify new mechanisms and concepts in the field of cellular communications, in order to develop new therapeutic strategies and diagnostic tools.
PLEIOTROPIC UROTENSIN II RECEPTOR SIGNALING PATHWAYS : KEY ROLES IN CELL MESENCHYMAL TRANSITION IN PATHOLOGICAL FUNCTIONS
CASTEL Hélène
(U982 Inserm; Neuronal and Neuroendocrine Cell Communication and Differentiation, DC2N, Platform cancer and cognition Institute of Research and Biomedical Innovation (IRIB) University of Rouen,)
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