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DTSTART;TZID=Europe/Paris:20260710T143000
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DTSTAMP:20260611T105911Z
CREATED:20260611
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PRIORITY:5
SEQUENCE:8
TRANSP:OPAQUE
SUMMARY:Thesis – Athénaïs GENIN
DESCRIPTION:Astrocyte remodeling in a murine model of Dravet syndrome\nJury\n\nAude PANATIER, Research Director, Neurocentre Magendie, Bordeaux – Reviewer\nGilles HUBERFELD, Hospital Practitioner, Adolphe de Rothschild Foundation Hospital, Paris – Reviewer\nElena AVIGNONE, Associate Professor, Neurocentre Magendie, Bordeaux – Examiner\nFrançois RASSENDREN, Research Director, IGF, University of Montpellier – Examiner\nEtienne AUDINAT, Research Director, IGF, University of Montpellier – Thesis supervisor\nNoémie CRESTO, Postdoctoral Researcher, IGF, University of Montpellier – Co-supervisor\n\nSummary\nDravet syndrome is a developmental and epileptic encephalopathy caused by loss-of-function variants in SCN1A. Although neuronal dysfunction is well documented, the contribution of astrocytes remains unclear. Using Scn1a+/− mice, we identified astrocyte remodeling during disease progression. Mice exhibited increased GFAP expression in the hippocampus and cortex, with transient morphological changes in CA1 astrocytes during the worsening stage. In contrast, functional alterations persisted, including increased astrocytic coupling, elevated connexin 30 and 43 expression, and reduced hemichannel activity. These changes were associated with enhanced post-tetanic potentiation at Schaffer collateral–CA1 synapses and occurred in the absence of major tissue damage.Our findings reveal long-lasting astrocytic remodeling in Dravet syndrome that may contribute to network hyperexcitability and associated cognitive and behavioral deficits.\n
URL:https://www.igf.cnrs.fr/en/events/thesis-athenais-genin/
CATEGORIES:Thesis
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