Institut de
Génomique
Fonctionnelle

Team : Signalling and cancer

 Progastrin and cancer stem cells in colorectal cancer
 Are beta-arrestins involved in colorectal tumorigenesis ?
 Are PKCs involved in the control of mRNA translation ?
 Role of the nuclear receptor PXR in cancer cells and in cancer stem cells in colorectal cancer
 Tight junction proteins in the regulation of intestinal cell differentiation and tumorigenesis

Tight junction proteins in the regulation of intestinal cell differentiation and tumorigenesis

Frédéric Hollande, CNRS Senior Research Fellow (DR2)

Recent team publications related to this project

1 : Buchert M, Papin M, Bonnans C, Darido C, Raye WS, Garambois V, Pélegrin A, Bourgaux JF, Pannequin J, Joubert D, Hollande F. Symplekin promotes tumorigenicity by up-regulating claudin-2 expression. Proc Natl Acad Sci U S A. 2010 Feb 9 ;107(6):2628-33.

2 : Buchert M, Darido C, Lagerqvist E, Sedello A, Cazevieille C, Buchholz F, Bourgaux JF, Pannequin J, Joubert D, Hollande F. The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1. Gastroenterology. 2009 Jul ;137(1):156-64, 164.e1-3.

3 : Darido C, Buchert M, Pannequin J, Bastide P, Zalzali H, Mantamadiotis T, Bourgaux JF, Garambois V, Jay P, Blache P, Joubert D, Hollande F. Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells. Cancer Res. 2008 Jun 1 ;68(11):4258-68.

4 : Pannequin J, Delaunay N, Darido C, Maurice T, Crespy P, Frohman MA, Balda MS, Matter K, Joubert D, Bourgaux JF, Bali JP, Hollande F. Phosphatidylethanol accumulation promotes intestinal hyperplasia by inducing ZONAB-mediated cell density increase in response to chronic ethanol exposure. Mol Cancer Res. 2007 Nov ;5(11):1147-57.

5 : Kavanagh E, Buchert M, Tsapara A, Choquet A, Balda MS, Hollande F, Matter K. Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin. J Cell Sci. 2006 Dec 15 ;119(Pt 24):5098-105.

6 : Boireau S, Buchert M, Samuel MS, Pannequin J, Ryan JL, Choquet A, Chapuis H, Rebillard X, Avancès C, Ernst M, Joubert D, Mottet N, Hollande F. DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma. Carcinogenesis. 2007 Feb ;28(2):246-58.

7 : Hollande F, Shulkes A, Baldwin GS. Signaling the junctions in gut epithelium. Sci STKE. 2005 Mar 29 ;2005(277):pe13.