Institut de
Génomique
Fonctionnelle

PUBLICATIONS since 2006 – a selection :

Weiss N, Hameed S, Fernandez-Fernandez JM, Fablet K, Karmazinova M, Poillot C, Proft J, Chen L, Bidaud I, Monteil A, Huc-Brandt S, Lacinova L, Lory P, Zamponi GW, De Waard M. A Cav3.2/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis. J Biol Chem. 2012, 287(4):2810-8.

Bidaud I, Lory P. Hallmarks of the channelopathies associated with L-type calcium channels : a focus on the Timothy mutations in Cav1.2 channels. Biochimie. 2011 93(12):2080-6.

Swayne LA, Mezghrani A, Lory P, Nargeot J, Monteil A. The NALCN ion channel is a new actor in pancreatic beta-cell physiology. Islets. 2010, 2(1):54-6. Review.

Lory P, Mezghrani A. Calcium channelopathies in inherited neurological disorders : relevance to drug screening for acquired channel disorders. IDrugs. 2010, 13(7):467-71. Review.

Zamponi GW, Lory P, Perez-Reyes E. Role of voltage-gated calcium channels in epilepsy. Pflugers Arch. 2010, 460(2):395-403.

Barbara G, Alloui A, Nargeot J, Lory P, Eschalier A, Bourinet E, Chemin J. T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids. J Neurosci. 2009, 29(42):13106-14.

Swayne LA, Mezghrani A, Varrault A, Chemin J, Bertrand G, Dalle S, Bourinet E, Lory P, Miller RJ, Nargeot J, Monteil A. The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line. EMBO Rep. 2009, 10(8):873-80.

Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers DM, Brown JH, Condorelli G. Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol. 2009, 184(6):923-33.

Huc S, Monteil A, Bidaud I, Barbara G, Chemin J, Lory P. Regulation of T-type calcium channels : signalling pathways and functional implications. Biochim Biophys Acta. 2009, 1793(6):947-52. Review.

Shcheglovitov A, Vitko I, Bidaud I, Baumgart JP, Navarro-Gonzalez MF, Grayson TH, Lory P, Hill CE, Perez-Reyes E. Alternative splicing within the I-II loop controls surface expression of T-type Cav3.1 calcium channels. FEBS Lett. 2008, 582(27):3765-70

Shuba YM, Perez-Reyes E, Lory P, Noebels J. T-type calcium channels : from discovery to channelopathies, 25 years of research. Channels. 2008, 2(4):299-302. Meeting report

Baumgart JP, Vitko I, Bidaud I, Kondratskyi A, Lory P, Perez-Reyes E. I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels. PLoS One. 2008, 3(8):e2976.

Mezghrani A, Monteil A, Watschinger K, Sinnegger-Brauns MJ, Barrère C, Bourinet E, Nargeot J, Striessnig J, Lory P. A destructive interaction mechanism accounts for dominant-negative effects of misfolded mutants of voltage-gated calcium channels. J Neurosci. 2008 28(17):4501-11

Chemin J, Mezghrani A, Bidaud I, Dupasquier S, Marger F, Barrère C, Nargeot J, Lory P. Temperature-dependent modulation of Cav3 T-type calcium channels by protein kinases C and A in mammalian cells. J Biol Chem. 2007, 282(45):32710-8.

Snutch TP, Monteil A. The sodium "leak" has finally been plugged. Neuron. 2007, 54(4):505-7.

Lory P, Chemin J. Towards the discovery of novel T-type calcium channel blockers. Expert Opin Ther Targets. 2007, 11(5):717-22. Review.

Singh B, Monteil A, Bidaud I, Sugimoto Y, Suzuki T, Hamano S, Oguni H, Osawa M, Alonso ME, Delgado-Escueta AV, Inoue Y, Yasui-Furukori N, Kaneko S, Lory P, Yamakawa K. Mutational analysis of CACNA1G in idiopathic generalized epilepsy. Hum Mutat. 2007, 28(5):524-5.

Chemin J, Patel AJ, Duprat F, Sachs F, Lazdunski M, Honore E. Up- and down-regulation of the mechano-gated K2P channel TREK-1 by PIP2 and other membrane phospholipids. Pflugers Arch. 2007, 455(1):97-103.

Vitko I, Bidaud I, Arias JM, Mezghrani A, Lory P, Perez-Reyes E. The I-II loop controls plasma membrane expression and gating of Cav3.2 T-type Ca2+ channels : a paradigm for childhood absence epilepsy mutations. J Neurosci. 2007, 27(2):322-30.

Chemin J, Nargeot J, Lory P. Chemical determinants involved in anandamide-induced inhibition of T-type calcium channels. J Biol Chem. 2007, 282(4):2314-23.

Traboulsie A, Chemin J, Chevalier M, Quignard JF, Nargeot J, Lory P. Subunit-specific modulation of T-type calcium channels by zinc. J Physiol. 2007, 578(1):159-71.

DePuy SD, Yao J, Hu C, McIntire W, Bidaud I, Lory P, Rastinejad F, Gonzalez C, Garrison JC, Barrett PQ. The molecular basis for T-type Ca2+ channel inhibition by G protein beta2gamma2 subunits. Proc Natl Acad Sci USA. 2006, 103(39):14590-5.

Chemin J, Traboulsie A, Lory P. Molecular pathways underlying the modulation of T-type calcium channels by neurotransmitters and hormones. Cell Calcium. 2006, 40(2):121-34. Review.

Lory P, Bidaud I, Chemin J. T-type calcium channels in differentiation and proliferation. Cell Calcium. 2006, 40(2):135-46. Review.

Mangoni ME, Traboulsie A, Leoni AL, Couette B, Marger L, Le Quang K, Kupfer E, Cohen-Solal A, Vilar J, Shin HS, Escande D, Charpentier F, Nargeot J, Lory P. Bradycardia and slowing of the atrioventricular conduction in mice lacking Cav3.1/alpha1G T-type calcium channels. Circ Res. 2006, 98(11):1422-30.