Institut de
Génomique
Fonctionnelle

Physiological and genetic aspects of cardioprotection




Team leader :

Matteo Mangoni, DR2 CNRS

Stéphanie Barrère-Lemaire, DR2 CNRS

Cardiovascular disease constitutes the first cause of mortality worldwide. We can estimate that in 2030 about 23.6 millions people will decease of cardiovascular disease. It is thus very important to constantly develop new therapeutic strategies. The cardiac performance is determined by the properties of pacemaker activity as well myocardial contractility. In humans, the heart rate is an important pronostic factor of morbidity and mortality. Our research team focuses on the cellular mechanisms underlying the genesis and control of cardiac automaticity and to elucidation of the cellular and molecular mechanisms underlying myocytes survival or death during cardiac ischemic processes. Our objective is to indicate new molecular targets for controlling heart rate and to protects the myocardium during ischemic heart disease .

The team is part of the labex ICST (Ion Channel Science and Therapeutics). http://www.labex-icst.fr/fr

RECENT PUBLICATIONS :

 Boisguérin P, Giorgi JM, Barrère-Lemaire S (2012) CPP-conjugated anti-apoptotic peptides as therapeutic tools of ischemia-reperfusion injuries. Curr Pharm Des, 2012 Nov 2. [Epub ahead of print] http://www.ncbi.nlm.nih.gov.gate1.i...

 Barrère-Lemaire S, Nargeot J and Piot C (2012) Delayed postconditioning : not too late ? Trends Cardiovasc Med 2012 Sep 5 [Epub ahead of print] http://www.ncbi.nlm.nih.gov.gate1.i...

 Khoueiry Z, Roubille C, Nagot N, Lattuca B, Piot C, Leclercq F, Delseny D, Busseuil D, Gervasoni R, Davy JM, Pasquié JL, Cransac F, Sportouch-Dukhan C, Macia JC, Cung TT, Massin F, Cade S, Cristol JP, Barrère-Lemaire S, Roubille F. (2012) Could heart rate play a role in pericardial inflammation ? Med Hypotheses. 2012 Oct ;79(4):512-5. doi : 10.1016/j.mehy.2012.07.006. Epub 2012 Aug 2. http://www.ncbi.nlm.nih.gov.gate1.i...

 Christel C, Cardona N, Mesirca P, Herrmann S, Hofmann F, Striessnig J, Ludwig A, Mangoni ME, Lee A (2012) Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node. J Physiol. 2012 Oct 8. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/...

 Neco P, Torrente A, Mesirca P, Zorio E, Liu N, Priori SG, Napolitano C, Richard S, Benitah JP, Mangoni ME, Gómez AM (2012) Paradoxical Effect of Increased Diastolic Ca2+ Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation. Jun 18. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/...

 Vincent A, Gahide G, Sportouch-Dukhan C, Roubille F, Adda J, Dantec C, Covinhès A, Franck-Miclo A, Redt-Clouet C., Barrère C, Piot C, Nargeot J and Barrère-Lemaire S (2012) Downregulation of the transcription factor Zac1 upon PreC and PostC protects against ischemia-reperfusion in the mouse myocardium. Cardiovascular research, 94(2):351-8. http://www.ncbi.nlm.nih.gov.gate1.i...

 Bock G, Gebhart M, Scharinger A, Jangsangthong W, Busquet P, Poggiani C, Sartori S, Mangoni ME, Sinnegger-Brauns MJ, Herzig S, Striessnig J and Koschak A (2011) Functional properties of a newly identified C-terminal splice variant of Cav1.3 L-type Ca2+ channels JBC, 286(49):42736-48. http://www.ncbi.nlm.nih.gov.gate1.i...

 Roubille F, Franck-Miclo A, Covinhes A, Lafont C, Cransac F, Combes S, Vincent A, Fontanaud P, Sportouch-Dukhan C, Redt-Clouet C, Nargeot J, Piot C, Barrère-Lemaire S. Delayed Postconditioning in the Mouse Heart In Vivo (2011) Circulation, 124(12):1330-6. http://www.ncbi.nlm.nih.gov/pubmed/...