Institut de
Génomique
Fonctionnelle

Team : Signalling and cancer

 Progastrin and cancer stem cells in colorectal cancer
 Are beta-arrestins involved in colorectal tumorigenesis ?
 Are PKCs involved in the control of mRNA translation ?
 Role of the nuclear receptor PXR in the chemoresistance of tumor cells and cancer stem cells in colorectal cancer
 Tight junction proteins in the regulation of intestinal cell differentiation and tumorigenesis

Are PKCs involved in the control of mRNA translation ?

Dominique Joubert, Inserm Senior Research Fellow (DR2), emeritat
Armelle Choquet, Lecturer, Université Montpellier 1
Françoise Macari, Lecturer, Université Montpellier 1
1 Engineer : Samer Khoury Hanna

Recent publications related to this project

1 : Dupasquier S, Abdel-Samad R, Glazer RI, Bastide P, Jay P, Joubert D, Cavaillès V, Blache P, Quittau-Prévostel C. A new mechanism of SOX9 action to regulate PKCalpha expression in the intestine epithelium. J Cell Sci. 2009 Jul 1 ;122(Pt 13):2191-6.

2 : Diouf B, Collazos A, Labesse G, Macari F, Choquet A, Clair P, Gauthier-Rouvière C, Guérineau NC, Jay P, Hollande F, Joubert D. A 20-amino acid module of protein kinase Cepsilon involved in translocation and selective targeting at cell-cell contacts. J Biol Chem. 2009 Jul 10 ;284(28):18808-15.

3 : Collazos A, Diouf B, Guérineau NC, Quittau-Prévostel C, Peter M, Coudane F,Hollande F, Joubert D. A spatiotemporally coordinated cascade of protein kinase Cactivation controls isoform-selective translocation. Mol Cell Biol. 2006 Mar ;26(6):2247-61.

4 : Quittau-Prévostel C, Delaunay N, Collazos A, Vallentin A, Joubert D. Targeting of PKCalpha and epsilon in the pituitary : a highly regulated mechanism involving a GD(E)E motif of the V3 region. J Cell Sci. 2004 Jan 1 ;117(Pt 1):63-72.