Institut de
Génomique
Fonctionnelle

Team : Signalling and cancer

 Progastrin and Cancer stem cells in colorectal cancer
 Are beta-arrestins involved in colorectal tumorigenesis ?
 Are PKCs involved in the control of mRNA translation ?
 Nucear receptors CAR and PXR : role in the chemoresistance of tumour cells in colorectal cancer
 Tight junction proteins in the regulation of intestinal cell differentiation and tumorigenesis

Progastrin and Cancer stem cells in colorectal cancer

Julie Pannequin, CNRS Research Fellow (CR1)
Frédéric Hollande, CNRS Research Fellow (DR2)
1 PhD student : Julie Giraud

Recent Team publications on this project

1 : Pannequin J, Bonnans C, Delaunay N, Ryan J, Bourgaux JF, Joubert D, Hollande F. The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells. Cancer Res. 2009 Aug 1 ;69(15):6065-73.

2 : Pannequin J, Delaunay N, Buchert M, Surrel F, Bourgaux JF, Ryan J, Boireau S, Coelho J, Pélegrin A, Singh P, Shulkes A, Yim M, Baldwin GS, Pignodel C, Lambeau G, Jay P, Joubert D, Hollande F. Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors. Gastroenterology. 2007 Nov ;133(5):1554-68.

3 : Hollande F, Lee DJ, Choquet A, Roche S, Baldwin GS. Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells. J Cell Sci. 2003 Apr 1 ;116(Pt 7):1187-97.

Brevets

 Hollande, F., D. Joubert, P. Jay, J. Pannequin, N. Delaunay, and J.-F. Bourgaux. 2006. Progastrin inhibitors in the treatment of colon cancer. EP 06290823.1. Published in November 2007 In World Intellectual Property Organization (WO2007135542).
 Pannequin, J., Boudier, L., Joubert, D. & Hollande, F. 2009. US 61/252,625. Monoclonal antibodies to progastrin and their uses. Published in April 2011 in World Intellectual Property Organization (WO2011045080).
 Floch, J.-F., L. Houhou, F. Cailler, D. Joubert, and F. Hollande. 2010. Methods for treating breast cancer. US 61/293,612. Published in July 2011 in World Intellectual Property Organization (WO2011083090).
 Houhou, L., D. Joubert, and F. Hollande. 2010. Methods for treating pancreatic cancer. US 61/293,612. Published in July 2011 in World Intellectual Property Organization (WO2011083091).
 Pannequin, J., L. Houhou, B. Framery, N. Erkilic, D. Joubert, and F. Hollande. 2010. Methods for treating colorectal cancer. US 61/293,612. Published in July 2011 in World Intellectual Property Organization (WO2011083088).
 Houhou, L., D. Joubert, F. Hollande and M. Petremann. 2010. Prophylaxis of colorectal and gastrointestinal cancer. US 61/317,245. Published in September 2011 in World Intellectual Property Organization (WO/2011/116954).