Signalling and cancer
par- 6 mai 2010
Team : Signalling and cancer
Intracellular signalling is in the center of the biology of the cell and connected with the controls implying the cell-cell and cell-environment relationships. The projects developed in our team take place in this context of integrated biology and focus on understanding mechanisms involved in tumorigenesis in global. Though, our team develops projects concerning initiation, dissemination or chemoresistance. Abnormal activation of Wnt and Notch pathways is in the heart of our studies as well as the impact of cancer stem cells (also named tumor initiating cells) in the above-cited processes. Our model varies from cell lines, to mice models as well as biopsies from patients with colorectal cancer thanks to collaborations with clinicians in different local hospitals. Our work has led to results with strong impact, for instance a therapeutic antibody directed against Progastrin undergoes pre clinical phase as a promising treatment for colorectal cancer management.
Recent selected publications
Bonnans C, Flacelière M, Grillet F, Dantec C, Desvignes JP, Pannequin J, Severac D, Dubois E, Bibeau F, Escriou V, Crespy P, Journot L, Hollande F, Joubert D.Essential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signaling. Proc Natl Acad Sci U S A. 2012 Feb 21 ;109(8):3047-52.
Raynal C, Pascussi JM, Leguelinel G, Breuker C, Kantar J, Lallemant B, Poujol S, Bonnans C, Joubert D, Hollande F, Lumbroso S, Brouillet JP, Evrard A.Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation. Mol Cancer. 2010 Mar 2 ;9:46.
Hollande F, Pannequin J, Joubert D.The long road to colorectal cancer therapy : searching for the right signals.Drug Resist Updat. 2010 Feb-Apr ;13(1-2):44-56.
Buchert M, Papin M, Bonnans C, Darido C, Raye WS, Garambois V, Pélegrin A, Bourgaux JF, Pannequin J, Joubert D, Hollande F.Symplekin promotes tumorigenicity by up-regulating claudin-2 expression. Proc Natl Acad Sci U S A. 2010 Feb 9 ;107(6):2628-33.
Lallemant B, Evrard A, Combescure C, Chapuis H, Chambon G, Raynal C, Reynaud C, Sabra O, Joubert D, Hollande F, Lallemant JG, Lumbroso S, Brouillet JP.Clinical. elevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinse.BMC Cancer. 2009 Oct 18 ;9:370.
Pannequin J, Bonnans C, Delaunay N, Ryan J, Bourgaux JF, Joubert D, Hollande F.The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells. Cancer Res. 2009 Aug 1 ;69(15):6065-73. Epub 2009 Jul 21.
Joubert D, Hollande F, Jay P, Legraverend C.Intestinal stem cells : thirty years of a long and exemplary story.Med Sci (Paris). 2009 May ;25(5):441-4.
Diouf B, Collazos A, Labesse G, Macari F, Choquet A, Clair P, Gauthier-Rouvière C, Guérineau NC, Jay P, Hollande F, Joubert D.A 20-amino acid module of protein kinase Cepsilon involved in translocation and selective targeting at cell-cell contacts. J Biol Chem. 2009 Jul 10 ;284(28):18808-15.
Pannequin, J., Boudier, L., Joubert, D. & Hollande, F. 2009. US 61/252,625. Monoclonal antibodies to progastrin and their uses. Published in April 2011 in World Intellectual Property Organization (WO2011045080).
Pannequin, J., L. Houhou, B. Framery, N. Erkilic, D. Joubert, and F. Hollande. 2010. Methods for treating colorectal cancer. US 61/293,612. Published in July 2011 in World Intellectual Property Organization (WO2011083088).