Synaptic plasticity in Drosophila
par- 5 mai 2010
Glutamatergic synapses mediate the majority of excitatory transmission, and changes in their transmission efficacy and architecture are thought to underlie higher cognitive processes. We use the fly Drosophila melanogaster to found new components playing a role in synaptic growth and activity. We also use this model to study the G protein-coupled receptors (GPCR) repertoire in insects, focusing on insects class III GPCRs (metabotropic glutamate receptors, GABAB receptors).
Techniques currently used in the lab are genetic, molecular genetic, molecular biology, pharmacology, and immunochemistry.