Institut de
Génomique
Fonctionnelle

Selection of publications over the 5 last years

2012

Cochet M, Donneger R, Cassier E, Gaven F, Lichtenthaler SF, Marin P, Bockaert J, Dumuis A, Claeysen S. 5-HT4 Receptors Constitutively Promote the Non-Amyloidogenic Pathway of APP Cleavage and Interact with ADAM10. ACS Chem. Neurosci. In press.

Skorupa A, King MA, Aparicio IM, Dussmann H, Coughlan K, Breen B, Kieran D, Concannon CG, Marin P, Prehn JH. (2012) Motoneurons secrete angiogenin to induce RNA cleavage in astroglia. J Neurosci. 2012 Apr 11.

Meffre J, Chaumont-Dubel S, Mannoury la Cour C, Loiseau F, Watson DJG, Dekeyne A, Séveno M, Rivet JM, Gaven F, Déléris P, Hervé D, Fone KCF, Bockaert J, Millan MJ, Marin P. (2012) 5-HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia. EMBO Molecular Medicine 2012 Oct 2.

Thouvenot E, Urbach S, Vigy O, Séveno M, Galéotti N, Nguyen G, Bockaert J, Marin P. (2012) Quantitative proteomic analysis reveals protein expression changes in the murine neuronal secretome during apoptosis. J Proteomics. 2012 Sep 23.

2011

Bockaert J., Claeysen S., Compan V. and Dumuis A. (2011) 5-HT(4) receptors, a place in the sun : act two. Curr Opin Pharmacol. 11:87-93.

Sucic S, El-Kasaby A, Kudlacek O, Sarker S, Sitte HH, Marin P, Freissmuth M. (2011) The serotonin transporter is an exclusive client of the COPII component SEC24C. J Biol Chem. 2011 Mar 17.

Jitsuki S, Takemoto K, Kawasaki T, Tada H, Takahashi A, Becamel C, Sano A, Yuzaki M, Zukin RS, Ziff EB, Kessels HW, Takahashi T. (2011) Serotonin mediates cross-modal reorganization of cortical circuits. Neuron. 2011 Feb 24 ;69(4):780-92.

Pellissier LP, Barthet G, Gaven F, Cassier E, Trinquet E, Pin JP, Marin P, Dumuis A, Bockaert J, Banères JL, Claeysen S. (2011) G Protein Activation by Serotonin Type 4 Receptor Dimers : Evidence That Turning On Two protomers Is More Efficient. J Biol Chem. 286:9985-97.

2010

Labasque M, Meffre J, Carrat G, Becamel C, Bockaert J, Marin P. (2010) Constitutive activity of serotonin 2C receptors at G protein-independent signaling : modulation by RNA editing and antidepressants. Mol Pharmacol. 78:818-26.

Pichon X, Wattiez AS, Becamel C, Ehrlich I, Bockaert J, Eschalier A, Marin P, Courteix C. (2010) Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Mol Ther. 18:1462-70.

Bockaert J, Perroy J, Bécamel C, Marin P, Fagni L. (2010) GPCR interacting proteins (GIPs) in the nervous system : Roles in physiology and pathologies. Annu Rev Pharmacol Toxicol. 50:89-109.

2009

Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier L, Augier J, Kang DS, Claeysen S, Reiter E, Banères J-L, Benovic JL, Marin P, Bockaert J, Dumuis A (2009) ß-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. EMBO J 28:2706-2718.

Pellissier L, Sallander J, Campillo M, Gaven F, Queffeulou E, Pillot M, Dumuis A, Claeysen S, Bockaert J, Pardo L (2009) Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol 75:982-990.

2008

Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL (2008) Engineering GPCR signaling pathways with RASSLs. Nat Methods 5:673-678.

Labasque M, Reiter E, Becamel C, Bockaert J, Marin P (2008) Physical Interaction of Calmodulin with the 5-HT2C Receptor C-terminus Is Essential for G Protein-independent, Arrestin-dependent, Receptor Signaling. Mol Biol Cell 19:4640-4650.

Thouvenot E, Urbach S, Dantec C, Poncet J, Seveno M, Demettre E, Jouin P, Touchon J, Bockaert J, Marin P (2008) Enhanced Detection of CNS Cell Secretome in Plasma Protein-Depleted Cerebrospinal Fluid. J Proteome Res 7:4409-4421.

2007

Delcourt N, Thouvenot E, Chanrion B, Galeotti N, Jouin P, Bockaert J, Marin P (2007) PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons. EMBO J 26:1542-1551.

Chanrion B, Mannoury la Cour C, Bertaso F, Lerner-Natoli M, Freissmuth M, Millan MJ, Bockaert J, Marin P (2007) Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc Natl Acad Sci U S A 104:8119-8124.

Barthet G, Framery B, Gaven F, Pellissier L, Reiter E, Claeysen S, Bockaert J, Dumuis A (2007) 5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling. Mol Biol Cell 18:1979-1991.

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