Team "Serotonin and Physiopathologies"
par- 26 novembre 2012
Group leader : Philippe MARIN, DR2 CNRS
Serotonin (5-hydroxytryptamine, 5-HT) is a major neurotransmitter of the mammalian central nervous system. Serotonin is involved in numerous physiological functions including the regulation of mood, cognitive functions, feeding, sleep and pain transmission. Alterations of serotonergic systems have been involved in numerous psychiatric disorders such as mood disorders and psychoses. Accordingly, 5-HT receptors and the serotonin transporter (SERT) are major targets of numerous psychoactive medications including the majority of currently available antidepressants and atypical antipsychotics. Using functional proteomics approaches, our team identifies signalling networks associated with various 5-HT receptors and the 5-HT transporter and characterizes their role in synaptic transmission and synaptic plasticity, cognition, mood and neuronal survival.
The team is affiliated to FondaMental (the network for scientific collaboration in mental health).
Meffre J, Chaumont-Dubel S, Mannoury la Cour C, Loiseau F, Watson DJG, Dekeyne A, Séveno M, Rivet JM, Gaven F, Déléris P, Hervé D, Fone KCF, Bockaert J, Millan MJ, Marin P. (2012) 5-HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia. EMBO Molecular Medicine 2012 Oct 2.
Barthet G, Carrat G, Cassier E, Barker B, Gaven F, Pillot M, Framery B, Pellissier L, Augier J, Kang DS, Claeysen S, Reiter E, Banères J-L, Benovic JL, Marin P, Bockaert J, Dumuis A (2009) ß-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling EMBO J 28:2706-2718.
Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL (2008) Engineering GPCR signaling pathways with RASSLs. Nat Methods 5:673-678.
Chanrion B, Mannoury la Cour C, Bertaso F, Lerner-Natoli M, Freissmuth M, Millan MJ, Bockaert J, Marin P (2007) Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc Natl Acad Sci U S A 104:8119-8124.
Delcourt N, Thouvenot E, Chanrion B, Galeotti N, Jouin P, Bockaert J, Marin P (2007) PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons. EMBO J 26:1542-1551.
Marin P., Thouvenot E., Nguyen G., Grozer M. (2012) New dual biomarkers of neurodegeneration and of neuroregeneration. EP n° 12 305 207.8 (22/02/2012).