Institut de
Génomique
Fonctionnelle

Equipe : Signalisation et Cancer

2009-2012

Guichet PO, Bieche I, Teigell M, Serguera C, Rothhut B, Rigau V, Scamps F, Ripoll C, Vacher S, Taviaux S, Chevassus H, Duffau H, Mallet J, Susini A, Joubert D, Bauchet L, Hugnot JP.Cell death and neuronal differentiation of glioblastoma stem-like cells induced by neurogenic transcription factors. Glia. 2012 Oct 9

Evrard A, Mbatchi L. Genetic polymorphisms of drug metabolizing enzymes and transporters : the long way from bench to bedside.Curr Top Med Chem. 2012 Aug 1 ;12(15):1720-9.

Ciccolini J, Evrard A, M’Batchi L, Pourroy B, Mercier C, Iliadis A, Lacarelle B, Verschuur A, Ouafik L, André N. CDA deficiency as a possible culprit for life-threatening toxicities after cytarabine plus 6-mercaptopurine therapy : pharmacogenetic investigations. Pharmacogenomics. 2012 Mar ;13(4):393-7.

Dahan L, Ciccolini J, Evrard A, Mbatchi L, Tibbitts J, Ries P, Norguet E, Mercier C, Iliadis A, Ouafik L, Lacarelle B, Seitz JF.Sudden death related to toxicity in a patient on capecitabine and irinotecan plus bevacizumab intake : pharmacogenetic implications. J Clin Oncol. 2012 Feb 1 ;30(4):e41-4.

Mouzat K, Mercier E, Polge A, Evrard A, Baron S, Balducchi JP, Brouillet JP, Lumbroso S, Gris JC. A common polymorphism in NR1H2 (LXRbeta) is associated with preeclampsia. BMC Med Genet. 2011 Oct 26 ;12:145. doi : 10.1186/1471-2350-12-145.

Buchert M, Turksen K, Hollande F. Methods to examine tight junction physiology in cancer stem cells : TEER, paracellular permeability, and dilution potential measurements. Stem Cell Rev. 2012 Sep ;8(3):1030-4.

Ayed-Boussema I, Pascussi JM, Rjiba K, Maurel P, Bacha H, Hassen W.The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes. Drug Chem Toxicol. 2012 Jul ;35(3):241-50. doi : 10.3109/01480545.2011.592194.

Schumacher MA, Donnelly JM, Engevik AC, Xiao C, Yang L, Kenny S, Varro A, Hollande F, Samuelson LC, Zavros Y. Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori.Gastroenterology. 2012 May ;142(5):1150-1159.e6.

Wörner M, Melchior K, Monostory K, Pascussi JM, Huber CG, Bernhardt R. The effects of rosuvastatin and the CYP51A1 inhibitor LEK-935 on the proteome of primary human hepatocytes. Drug Metab Dispos. 2012 Mar ;4(3):414-8.

Ayed-Boussema I, Pascussi JM, Maurel P, Bacha H, Hassen W. Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes. Int J Toxicol. 2012 Jan-Feb ;31(1):86-93.

Bonnans C, Flacelière M, Grillet F, Dantec C, Desvignes JP, Pannequin J, Severac D, Dubois E, Bibeau F, Escriou V, Crespy P, Journot L, Hollande F, Joubert D.Essential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signaling. Proc Natl Acad Sci U S A. 2012 Feb 21 ;109(8):3047-52.

Ciccolini J, Evrard A, Lacarelle B. A CDD polymorphism as predictor of capecitabine-induced hand-foot syndrome—letter. Clin Cancer Res. 2012 Jan 1 ;18(1):317.

Escobar M, Nicolas P, Sangar F, Laurent-Chabalier S, Clair P, Joubert D, Jay P, Legraverend C. Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation. Nat Commun. 2011 Mar 29 ;2:258.

Hollande F, Joubert D.Mitotic spindle and asymmetric stem cell division. Med Sci (Paris). 2010 Dec ;26(12):1027-30. French.

Schmitt A, Gladieff L, Laffont CM, Evrard A, Boyer JC, Lansiaux A, Bobin-Dubigeon C, Etienne-Grimaldi MC, Boisdron-Celle M, Mousseau M, Pinguet F, Floquet A, Billaud EM, Durdux C, Le Guellec C, Mazières J, Lafont T, Ollivier F, Concordet D, Chatelut E.Factors for hematopoietic toxicity of carboplatin : refining the targeting of carboplatin systemic exposure. J Clin Oncol. 2010 Oct 20 ;28(30):4568-74.

Xiao C, Ogle SA, Schumacher MA, Schilling N, Tokhunts RA, Orr-Asman MA, Miller ML, Robbins DJ, Hollande F, Zavros Y. Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions. Am J Physiol Gastrointest Liver Physiol. 2010 Dec ;299(6):G1252-65.

Raynal C, Pascussi JM, Leguelinel G, Breuker C, Kantar J, Lallemant B, Poujol S, Bonnans C, Joubert D, Hollande F, Lumbroso S, Brouillet JP, Evrard A. Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation. Mol Cancer. 2010 Mar 2 ;9:46.

Hollande F, Pannequin J, Joubert D. The long road to colorectal cancer therapy : searching for the right signals. Drug Resist Updat. 2010 Feb-Apr ;13(1-2):44-56. Review.

Dupasquier S, Abdel-Samad R, Glazer RI, Bastide P, Jay P, Joubert D, Cavaillès V, Blache P, Quittau-Prévostel C.A new mechanism of SOX9 action to regulate PKCalpha expression in the intestine epithelium.J Cell Sci. 2009 Jul 1 ;122(Pt 13):2191-6.

Buchert M, Papin M, Bonnans C, Darido C, Raye WS, Garambois V, Pélegrin A, Bourgaux JF, Pannequin J, Joubert D, Hollande F. Symplekin promotes tumorigenicity by up-regulating claudin-2 expression. Proc Natl Acad Sci U S A. 2010 Feb 9 ;107(6):2628-33.

Sirvent A, Bénistant C, Pannequin J, Veracini L, Simon V, Bourgaux JF, Hollande F, Cruzalegui F, Roche S.Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization. Oncogene. 2010 Mar 4 ;29(9):1303-15.

Xie JH, Hollande F, Haynes JM, Pouton CW, Ventura S. Troubleshooting immunohistochemical labelling of proliferating cell nuclear antigen (PCNA) in cryocut tissue sections of mouse prostate. J Pharmacol Toxicol Methods. 2010 Mar-Apr ;61(2):98-101

Xiao C, Ogle SA, Schumacher MA, Orr-Asman MA, Miller ML, Lertkowit N, Varro A, Hollande F, Zavros Y.Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology. 2010 Feb ;138(2):550-61, 561.e1-8.

Raynal C, Ciccolini J, Mercier C, Boyer JC, Polge A, Lallemant B, Mouzat K, Lumbroso S, Brouillet JP, Evrard A. High-resolution melting analysis of sequence variations in the cytidine deaminase gene (CDA) in patients with cancer treated with gemcitabine. Ther Drug Monit. 2010 Feb ;32(1):53-60.

Ciccolini J, Dahan L, André N, Evrard A, Duluc M, Blesius A, Yang C, Giacometti S, Brunet C, Raynal C, Ortiz A, Frances N, Iliadis A, Duffaud F, Seitz JF, Mercier C. Cytidine deaminase residual activity in serum is a predictive marker of early severe toxicities in adults after gemcitabine-based chemotherapies. J Clin Oncol. 2010 Jan 1 ;28(1):160-5.

Lallemant B, Evrard A, Combescure C, Chapuis H, Chambon G, Raynal C, Reynaud C, Sabra O, Joubert D, Hollande F, Lallemant JG, Lumbroso S, Brouillet JP. Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinse. BMC Cancer. 2009 Oct 18 ;9:370.

Lallemant B, Evrard A, Combescure C, Chapuis H, Chambon G, Raynal C, Reynaud C, Sabra O, Joubert D, Hollande F, Lallemant JG, Lumbroso S, Brouillet JP Reference gene selection for head and neck squamous cell carcinoma gene expression studies. BMC Mol Biol. 2009 Aug 3 ;10:78.

Pannequin J, Bonnans C, Delaunay N, Ryan J, Bourgaux JF, Joubert D, Hollande F. The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells. Cancer Res. 2009 Aug 1 ;69(15):6065-73.

Dworkin S, Malaterre J, Hollande F, Darcy PK, Ramsay RG, Mantamadiotis T. cAMP response element binding protein is required for mouse neural progenitor cell survival and expansion. Stem Cells. 2009 Jun ;27(6):1347-57.

Joubert D, Hollande F, Jay P, Legraverend C.Intestinal stem cells : thirty years of a long and exemplary story.Med Sci (Paris). 2009 May ;25(5):441-4. French.

Diouf B, Collazos A, Labesse G, Macari F, Choquet A, Clair P, Gauthier-Rouvière C, Guérineau NC, Jay P, Hollande F, Joubert D. A 20-amino acid module of protein kinase Cepsilon involved in translocation and selective targeting at cell-cell contacts. J Biol Chem. 2009 Jul 10 ;284(28):18808-15.

Buchert M, Darido C, Lagerqvist E, Sedello A, Cazevieille C, Buchholz F, Bourgaux JF, Pannequin J, Joubert D, Hollande F.The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1.Gastroenterology. 2009 Jul ;137(1):156-64, 164.e1-3.

Brevet :

 Hollande, F., D. Joubert, P. Jay, J. Pannequin, N. Delaunay, and J.-F. Bourgaux. 2006. Progastrin inhibitors in the treatment of colon cancer. EP 06290823.1. Published in November 2007 In World Intellectual Property Organization (WO2007135542).
 Pannequin, J., Boudier, L., Joubert, D. & Hollande, F. 2009. US 61/252,625. Monoclonal antibodies to progastrin and their uses. Published in April 2011 in World Intellectual Property Organization (WO2011045080).
 Floch, J.-F., L. Houhou, F. Cailler, D. Joubert, and F. Hollande. 2010. Methods for treating breast cancer. US 61/293,612. Published in July 2011 in World Intellectual Property Organization (WO2011083090).
 Houhou, L., D. Joubert, and F. Hollande. 2010. Methods for treating pancreatic cancer. US 61/293,612. Published in July 2011 in World Intellectual Property Organization (WO2011083091).
 Pannequin, J., L. Houhou, B. Framery, N. Erkilic, D. Joubert, and F. Hollande. 2010. Methods for treating colorectal cancer. US 61/293,612. Published in July 2011 in World Intellectual Property Organization (WO2011083088).
 Houhou, L., D. Joubert, F. Hollande and M. Petremann. 2010. Prophylaxis of colorectal and gastrointestinal cancer. US 61/317,245. Published in September 2011 in World Intellectual Property Organization (WO/2011/116954).