Institut de
Génomique
Fonctionnelle

 Dalle S., Burcelin R., Gourdy P. Specific actions of GLP-1 receptor agonists and DPP4 inhibitors for the treatment of pancreatic β-cell impairements in type 2 diabetes (2012) Cell Signalling, in press

 Tarasov Al., Semplici F., Li D., Rizzuto R., Ravier MA., Gilon P., Rutter GA. Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic ß cells. (2012) Pflugers Arch, Nov 14. [Epub ahead of print]

 Tarasov Al., Semplici F., ravier MA., Bellomo EA., Pullen TJ., Gilon P., Sekler I., Rizzuto R., Rutter GA. The mitochondrial Ca(2+) uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells. (2012) Plos One, 7(7), e39722. Epub 2012 Jul 19

 Ravier MA., Daro D., Prates Roma L., Jonas JC., Cheng-Xue R., Schuit FC., Gilon P. Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic β-cells : interplay with cell metabolism and [Ca2+]c, and role of SERCA2b and SERCA3. (2011) Diabetes, 60, 2533-2445

 Dalle S., Quoyer J., Varin E., Costes S. Roles and regulation of the transcription factor CREB in pancreatic β-cells. (2011) Curr Mol Pharmacol, 4, 187-195

 Dalle S., Ravier MA., Bertrand G. Emerging roles for β-arrestin 1 in the control of pancreatic β-cells function and mass : New therapeutic strategies and consequences for drug screening. (2011) Cell Signalling, 23, 522-528

 Wong WP., Tiano JP., Liu S., Hewitt SC., Le May C., Dalle S., Katzenellenbogen JA., Katzenellenbogen BS., Korach KS., Mauvais-Jarvis F. Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis. (2010) Proc Natl Acad Sci USA, 107,13057-13062

 Quoyer J., Longuet C., Broca C., Linck N., Costes S., Varin E., Bockaert J., Bertrand G., Dalle S. GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a β-arrestin 1-mediated ERK1/2 activation in pancreatic β-cells. (2010) J Biol Chem, 285, 1989-2002

 Lemaire K., Ravier M.A., Schraenen A., Creemers J.W., Van de Plas R., Granvik M., Van Lommel L., Waelkens E., Chimienti F., Rutter G.A., Gilon P., in’t Veld P.A. and Schuit F.C. Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. (2009) Proc Natl Acad Sci USA, 106, 14872-14877

 Swayne LA., Mezghrani A., Varrault A., Chemin J., Bertrand G., Bourinet E., Dalle S., Miller RJ., Nargeot J., Monteil A. The NALCN cation channel is activated by M3 muscarinic receptors independently of G proteins in a pancreatic β-cell line. (2009) EMBO Report, 10, 873-880

 Annicotte JS., Blanchet E., Chavey C., Iankova I., Costes S., Assou S., Teyssier J., Dalle S., Sardet C., Fajas L. The CDK4-pRB-E2F1 pathway controls insulin secretion. (2009) Nat Cell Biol, 11, 1017-1023

 Costes S., Vandewalle B., Tourrel-Cuzin C., Broca C., Linck N., Bertrand G., Kerr-Conte J., Portha B., Pattou F., Bockaert J., Dalle S. Degradation of cAMP-Responsive Element-Binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in β-cells and human pancreatic islets. (2009) Diabetes, 58, 1105-1115

 Broca C., Quoyer J., Costes S., Linck N., Varrault A., Deffayet PM., Bockaert J., Dalle S., Bertrand G. β-arrestin 1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic β-cells. (2009) J Biol Chem, 284, 4332-4342

 Costes S., Broca C., Bertrand G., Lajoix AD., Bataille D., Bockaert J., Dalle S. ERK1/2 Control phosphorylation and protein level of cAMP-Responsive Element-Binding protein : A key role in glucose-mediated pancreatic β-cells survival. (2006) Diabetes, 55, 2220-2230

 Longuet C., Broca C., Costes S., Hani EH., Bataille D., Dalle S. ERK1/2 (p44/42 MAP kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 cell and islets of Langerhans. (2005) Endocrinology, 146, 643-654